Liu Wenting, Gong Lan
Department of Ophthalmology and Vision Science, The Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, P.R. China.
NHC Key Laboratory of Myopia, Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai 200031, P.R. China.
Exp Ther Med. 2021 Apr;21(4):338. doi: 10.3892/etm.2021.9769. Epub 2021 Feb 10.
infection gradually develops to blepharitis, which is characterized as chronic inflammation of the eyelid and meibomian gland (MG) and ultimately leads to MG dysfunction. In the present prospective study, the anti-demodectic effects of an okra eyelid patch in patients blepharitis were investigated. A total of 52 patients with blepharitis with ocular discomfort were recruited. Patients were randomized to receive either an okra eyelid patch treatment (treatment group, n=27) or tea tree oil (TTO) eye care patch treatment (control group, n=25) for three months. The count, the ocular surface disease index (OSDI) score, MG expressibility (MGE) and meibum quality, Schirmer I test (SIT), tear break-up time (TBUT) and corneal fluorescein staining (CFS) were determined prior to treatment and after 1 and 3 months of treatment. Changes in the parameters were compared between the treatment group and control group after 1 and 3 months of treatment. The average survival time in the okra group was 115.25±11.87 min, which was significantly lower compared with the average ST of 378.75±37.94 min in the blank group (P<0.01). After 3 months of okra eyelid patch treatment, the count was significantly reduced from 10.15±4.53 to 1.30±1.41 (P<0.01) and the OSDI score of the patients was reduced by 16.84±10.17 (P<0.01). There was no significant difference in the count (P=0.716) and OSDI (P=0.873) between the treatment and control groups. The rate of complete x eradication in the treatment group (11/27, 40.74%) was slightly lower than that in the control group (12/25, 48%), but there was no significant difference between the two groups (χ=0.277, P=0.598). Regarding the other ocular parameters, no significant difference was observed in the TBUT, meibum quality and MGE between the two groups (P<0.05). TTO group has a significantly improvement compared with Okra group in terms of SIT (P=0.035) and CFS (P=0.023). In conclusion, okra eyelid patch treatment is able to significantly eradicate ocular as well as markedly alleviate ocular symptoms. Due to causing less irritation than TTO, the okra eyelid patch may be more suitable for sensitive patients with blepharitis, such as the elderly and children. The study was registered as a clinical trial in the Chinese Clinical Trial Registry (ChiCTR) in November 2018 (registration no. ChiCTR-1,800,019,466).
感染逐渐发展为睑缘炎，其特征为眼睑和睑板腺（MG）的慢性炎症，并最终导致MG功能障碍。在本前瞻性研究中，研究了秋葵眼睑贴片对睑缘炎患者的抗蠕形螨作用。共招募了52例有眼部不适的睑缘炎患者。患者被随机分为接受秋葵眼睑贴片治疗（治疗组，n = 27）或茶树油（TTO）眼部护理贴片治疗（对照组，n = 25），为期三个月。在治疗前以及治疗1个月和3个月后，测定螨虫计数、眼表疾病指数（OSDI）评分、MG可表达性（MGE）和睑脂质量、Schirmer I试验（SIT）、泪膜破裂时间（TBUT）和角膜荧光素染色（CFS）。在治疗1个月和3个月后，比较治疗组和对照组之间参数的变化。秋葵组的平均存活时间为115.25±11.87分钟，与空白组平均存活时间378.75±37.94分钟相比显著更低（P<0.01）。经过3个月的秋葵眼睑贴片治疗后，螨虫计数从10.15±4.53显著降低至1.30±1.41（P<0.01），患者的OSDI评分降低了16.84±10.17（P<0.01）。治疗组和对照组之间的螨虫计数（P = 0.716）和OSDI（P = 0.873）无显著差异。治疗组的完全清除率（11/27，40.74%）略低于对照组（12/25，48%），但两组之间无显著差异（χ=0.277，P = 0.598）。关于其他眼部参数，两组之间在TBUT、睑脂质量和MGE方面未观察到显著差异（P<0.05）。在SIT（P = 0.035）和CFS（P = 0.023）方面，TTO组与秋葵组相比有显著改善。总之,秋葵眼睑贴片治疗能够显著清除眼部螨虫并明显缓解眼部症状。由于比TTO引起的刺激更少，秋葵眼睑贴片可能更适合睑缘炎敏感患者，如老年人和儿童。该研究于2018年11月在中国临床试验注册中心（ChiCTR）注册为一项临床试验（注册号：ChiCTR-1,800,019,466）。
