Wu Zhengjie, Huang Shunmei, Zheng Xiaoqin, Gu Silan, Xu Qiaomai, Gong Yiwen, Zhang Jiaying, Fu Bin, Tang Lingling
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
Department of Geriatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
Exp Ther Med. 2021 Apr;21(4):351. doi: 10.3892/etm.2021.9782. Epub 2021 Feb 11.
Liver fibrosis (LF) is a continuous wound healing process caused by numerous chronic hepatic diseases and poses a major threat to human health. Activation of hepatic stellate cells (HSCs) is a critical event in the development of hepatic fibrosis. Long non-coding RNAs (lncRNAs) that are involved in HSC activation, participate in the development of LF and are likely to be therapeutic targets for LF. In the present review, the cellular signaling pathways of LF with respect to HSCs were discussed. In particular, this present review highlighted the current knowledge on the role of lncRNAs in activating or inhibiting LF, revealing lncRNAs that are likely to be biomarkers or therapeutic targets for LF. Additional studies should be performed to elucidate the potential of lncRNAs in the diagnosis and prognosis of LF and to provide novel therapeutic approaches for the reversion of LF.
肝纤维化（LF）是由多种慢性肝病引起的持续伤口愈合过程，对人类健康构成重大威胁。肝星状细胞（HSCs）的激活是肝纤维化发展中的关键事件。参与肝星状细胞激活的长链非编码RNA（lncRNAs）参与肝纤维化的发展，可能成为肝纤维化的治疗靶点。在本综述中，讨论了与肝星状细胞相关的肝纤维化细胞信号通路。特别是，本综述强调了关于lncRNAs在激活或抑制肝纤维化中的作用的当前知识，揭示了可能成为肝纤维化生物标志物或治疗靶点的lncRNAs。应进行更多研究以阐明lncRNAs在肝纤维化诊断和预后中的潜力，并为肝纤维化的逆转提供新的治疗方法。
