Feng Lin, Lin Yan, Wang Leilei, Chen Hongxiao, Gao Min, Liu Huaxu, Yang Hongyu
Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Front Med (Lausanne). 2021 Feb 24;8:649438. doi: 10.3389/fmed.2021.649438. eCollection 2021.
To investigate the application of reflectance confocal microscopy (RCM) imaging in diagnosis of vulva syringoma. Patients with lesions suspicious of syringoma on vulva were enrolled in the study. After informed consent was taken, the lesions were photographed and imaged with RCM. The features of the lesion in confocal images were then analyzed and compared with the biopsy findings for histology correlation. Eleven cases in total were included in the study. The typical RCM features observed in syringoma are the presence of round to oval high refractive, and relatively monomorphous mass of varying sizes in the superficial and middle dermis, usually surrounded with 1-2 layers of light-dark line structures, which were further confirmed by histological evaluation. Ten cases showed classic features of syringoma and 1 case exhibited milia in RCM images. Syringoma has distinct features in RCM imaging, which correlates well with histological findings, highlighting the potential role of RCM in the diagnosis and differential diagnosis of vulva syringoma.
探讨反射式共聚焦显微镜（RCM）成像在外阴汗管瘤诊断中的应用。纳入外阴部有可疑汗管瘤病变的患者。在获得知情同意后，用RCM对病变进行拍照和成像。然后分析共聚焦图像中病变的特征，并与活检结果进行比较以进行组织学相关性分析。该研究共纳入11例患者。汗管瘤在RCM中观察到的典型特征是在真皮浅层和中层存在圆形至椭圆形的高折射、大小不一且相对单一形态的团块，通常被1 - 2层明暗相间的线状结构所包围，组织学评估进一步证实了这一点。10例在RCM图像中显示出汗管瘤的典型特征，1例表现为粟丘疹。汗管瘤在RCM成像中有明显特征，与组织学结果相关性良好，突出了RCM在外阴汗管瘤诊断及鉴别诊断中的潜在作用。
