Abdulla Maheeba, Ghuloom Mohamed, Nass Hafsa, Mohammed Nafeesa, Farid Eman, ALQamish Jehad
Internal Medicine Department Salmaniya Medical Complex Manama Bahrain.
Salmaniya Medical Complex Manama Bahrain.
JGH Open. 2021 Feb 8;5(3):337-342. doi: 10.1002/jgh3.12494. eCollection 2021 Mar.
Hepatitis B e (HBe) antigen (HBeAg) is commonly encountered among hepatitis B patients and is indicative of active infection. There is a lack of data in the literature about the prevalence of HBeAg among hepatitis B patients in Bahrain and its impact on the disease. The aims of this study were to investigate the prevalence of HBeAg among a sample of hepatitis B patients in Bahrain and to analyze their associated laboratory profile, radiological characteristics, comorbidities, and complications.
This was a retrospective record-review study conducted on patients' records at Salmaniya Medical Complex hospital in Bahrain during the period of 2011-2016. All records of hepatitis B patients who had HBeAg tests performed were included in this study.
Of 323 patients recruited, 18.9% had positive HBeAg. The prevalence of anti-HBe antibodies and hepatitis B core immunoglobulin G (HBc IgG) differed significantly between patients with positive and negative HBeAg ( < 0.001, = 0.026, respectively). Alanine transferase and gamma-glutamyl transferase were significantly higher among patients with positive HBeAg ( = 0.017, = 0.016, respectively). There was no significant difference with regard to the prevalence of hepatitis C virus, human immunodeficiency virus, hepatocellular carcinoma, or liver transplantation between HBe-positive and -negative patients ( ≥ 0.05).
HBeAg is prevalent among hepatitis B patients in Bahrain and is associated with a significantly different laboratory profile.
乙肝e抗原（HBeAg）在乙肝患者中较为常见，提示存在活动性感染。关于巴林乙肝患者中HBeAg的患病率及其对疾病的影响，文献资料较少。本研究旨在调查巴林乙肝患者样本中HBeAg的患病率，并分析其相关的实验室检查结果、影像学特征、合并症及并发症。
这是一项回顾性病历审查研究，对2011年至2016年期间巴林萨勒曼尼亚医疗中心医院患者的病历进行分析。纳入所有进行过HBeAg检测的乙肝患者病历。
在纳入的323例患者中，18.9%的患者HBeAg呈阳性。HBeAg阳性和阴性患者的抗-HBe抗体及乙肝核心免疫球蛋白G（HBc IgG）患病率差异有统计学意义（分别为<0.001和=0.026）。HBeAg阳性患者的丙氨酸转氨酶和γ-谷氨酰转移酶显著更高（分别为=0.017和=0.016）。HBe阳性和阴性患者在丙型肝炎病毒、人类免疫缺陷病毒、肝细胞癌或肝移植的患病率方面无显著差异（≥0.05）。
HBeAg在巴林乙肝患者中普遍存在，且与显著不同的实验室检查结果相关。
