Magnetic Resonance Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
STAR Protoc. 2021 Mar 2;2(1):100355. doi: 10.1016/j.xpro.2021.100355. eCollection 2021 Mar 19.
Liver fat content and the linked rate of export of triglyceride are central to the etiology of type 2 diabetes, as well as to the cardiovascular effects of fatty liver disease. Measurement in humans of intrahepatic and intrapancreatic fat content is described using magnetic resonance techniques and quantification of the rate of hepatic secretion of very low density lipoprotein using a non-isotopic competitive blocking of tissue uptake. This protocol is non-invasive, can be repeated sequentially, and does not involve ionizing radiation. For complete details on the use and execution of this protocol, please refer to (Taylor et al., 2018) and (Al-Mrabeh et al., 2020b).
肝脏脂肪含量和甘油三酯的输出率与 2 型糖尿病的病因有关，也与脂肪肝的心血管影响有关。本文使用磁共振技术描述了肝内和胰内脂肪含量的测量，并使用非放射性同位素竞争组织摄取阻断法定量了肝脏分泌极低密度脂蛋白的速率。该方案是非侵入性的，可以连续重复进行，并且不涉及电离辐射。有关该方案的使用和执行的完整详细信息，请参考（Taylor 等人，2018 年）和（Al-Mrabeh 等人，2020b）。
