Zou Youliang, Zhang Binfeng, Wang Li, Zhang Hua
Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education and Hubei Key Laboratory of Catalysis and Materials Science, School of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China.
College of Chemistry, Nanchang University, Nanchang 330031, China.
Org Lett. 2021 Apr 2;23(7):2821-2825. doi: 10.1021/acs.orglett.1c00809. Epub 2021 Mar 18.
A benzoic acid-promoted C2-H borylation of indoles with pinacolborane to afford C2-borylated indoles is developed. Preliminary mechanistic studies indicate BH-related borane species formed via the decomposition of pinacolborane to be the probable catalyst. This transformation provides a prompt route toward the synthesis of diverse C2-functionalized indoles.
开发了一种苯甲酸促进的吲哚与频哪醇硼烷的C2-H硼化反应，以得到C2-硼化吲哚。初步机理研究表明，通过频哪醇硼烷分解形成的与BH相关的硼烷物种可能是催化剂。这种转化为合成各种C2-官能化吲哚提供了一条便捷的途径。
