锌催化吲哚的 C3-H 硼化和末端炔烃的 1,1-二硼化反应。
Zinc catalysed C3-H borylation of indoles and 1,1-diboration of terminal alkynes.
机构信息
Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, South-Central University for Nationalities, Wuhan 430074, China.
College of Chemistry, Nanchang University, Nanchang 330031, China.
出版信息
Chem Commun (Camb). 2021 Oct 26;57(85):11185-11188. doi: 10.1039/d1cc04497d.
A low catalyst loading Zn(OTf)-catalysed C3-H borylation of indoles with pinacolborane was developed. This transformation represents the use of an abundant, cheap and environmentally benign zinc catalyst in catalytic direct aromatic C-H borylation and offers a simple and prompt route towards the synthesis of C3-borylated indoles. The 1,1-diboration of terminal alkynes was also achieved using the same catalytic system to produce 1,1-diborylated alkenes.
发展了一种低催化剂负载量的 Zn(OTf)-催化吲哚的 C3-H 硼化反应，使用频哪醇硼烷作为硼源。这种转化代表了在催化直接芳基 C-H 硼化中使用丰富、廉价和环境友好的锌催化剂，并为合成 C3-硼化吲哚提供了一种简单、快速的途径。同样的催化体系也可用于末端炔烃的 1,1-二硼化反应，生成 1,1-二硼化烯烃。
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