Department of Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Psychol Health Med. 2022 Aug;27(7):1553-1562. doi: 10.1080/13548506.2021.1903052. Epub 2021 Mar 18.
Evidence shows that undernutrition during early life is associated with an increased risk of chronic diseases in adulthood. We aimed to investigate whether exposure to the Chinese famine in the fetal or infant stage was associated with self-reported arthritis risk in adulthood. A total of 3,622 participants were included in the final analysis. Participants were classified into non-, fetal-, and infant-exposed group. Arthritis was self-reported doctor-diagnosed arthritis. A multivariate logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of arthritis. The prevalence of arthritis was 27.07%, 27.74%, and 34.09% among individuals in non-, fetal-, infant-exposed group, respectively. Infant-exposed group (OR: 1.32; 95% CI: 1.12-1.56) had a higher arthritis risk then non-exposed group after adjustment for gender, age, area, education level, smoking status, drinking status, and physical activity. Participants who experienced severe famine during infant and fetal period had higher (41.46%, OR=1.71 and 32.94%, OR=1.36) arthritis risk than those exposed to less severe famine. Exposure to the Chinese famine in early life was associated with an increased risk of arthritis in adulthood, which was partially influenced by some factors (e.g., gender, area, body mass index, and born in severely affected area or not).
证据表明，生命早期的营养不良与成年后患慢性病的风险增加有关。我们旨在研究胎儿期或婴儿期暴露于中国饥荒是否与成年后自我报告的关节炎风险相关。共有 3622 名参与者被纳入最终分析。参与者被分为非暴露组、胎儿暴露组和婴儿暴露组。关节炎是自我报告的经医生诊断的关节炎。采用多变量逻辑回归模型计算关节炎的比值比（OR）和 95%置信区间（CI）。非暴露组、胎儿暴露组和婴儿暴露组的关节炎患病率分别为 27.07%、27.74%和 34.09%。调整性别、年龄、地区、教育水平、吸烟状况、饮酒状况和身体活动后，与非暴露组相比，婴儿暴露组（OR：1.32；95%CI：1.12-1.56）的关节炎风险更高。在婴儿期和胎儿期经历严重饥荒的参与者的关节炎风险更高（41.46%，OR=1.71 和 32.94%，OR=1.36），比暴露于轻度饥荒的参与者更高。生命早期暴露于中国饥荒与成年后患关节炎的风险增加有关，这部分受到一些因素的影响（例如，性别、地区、体重指数以及是否出生在受影响严重的地区等）。
