Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan ; and.
Sonoda Eye and Plastic Surgery Clinic, Kagoshima, Japan .
Retina. 2021 Oct 1;41(10):2148-2156. doi: 10.1097/IAE.0000000000003166.
To quantify the vessels of Haller's layer of normal subjects in en-face optical coherence tomographic images.
One hundred and seventy-two normal eyes were studied. En-face images of the top 25% slab of Haller's layer was analyzed. The vessel area, vessel length, and mean vessel diameter were calculated. The vessel running pattern was quantified for the degree of symmetry and designated as the "symmetry index." The coefficient of correlation between each choroidal parameter and the age, sex, axial length, and central choroidal thickness was determined.
The vessel area was 23.4 ± 3.6 mm2, vessel length was 164.6 ± 24.1 mm, mean vessel diameter was 0.143 ± 0.019 mm, and the symmetry index was 58.6 ± 6.1%. Multiple regression analysis showed that the vessel area was significantly correlated with the age (R = -0.421, P < 0.001) and central choroidal thickness (R = 0.315, P < 0.001). The vessel length was significantly correlated with the age (R = -0.391, P = 0.024) and central choroidal thickness (R = -0.410, P < 0.001). The mean vessel diameter was significantly correlated with the age (R = -0.107, P = 0.024) and central choroidal thickness (R = 0.775, P < 0.001). The correlation between the symmetry index and any clinical findings was not significant.
Quantification of en-face images of Haller's layer provide new biomarkers of the choroid.
定量分析正常人群 Haller 层的血管。
研究了 172 只正常眼。对 Haller 层顶部 25%的切片进行了共焦光学相干断层扫描图像分析。计算了血管面积、血管长度和平均血管直径。通过对称性程度量化了血管运行模式，并将其指定为“对称性指数”。确定了每个脉络膜参数与年龄、性别、眼轴长度和中心脉络膜厚度之间的相关系数。
血管面积为 23.4±3.6mm²，血管长度为 164.6±24.1mm，平均血管直径为 0.143±0.019mm，对称性指数为 58.6±6.1%。多元回归分析显示，血管面积与年龄（R=-0.421，P<0.001）和中心脉络膜厚度（R=0.315，P<0.001）显著相关。血管长度与年龄（R=-0.391，P=0.024）和中心脉络膜厚度（R=-0.410，P<0.001）显著相关。平均血管直径与年龄（R=-0.107，P=0.024）和中心脉络膜厚度（R=0.775，P<0.001）显著相关。对称性指数与任何临床发现之间的相关性均不显著。
Haller 层共焦光学相干断层扫描图像的定量分析为脉络膜提供了新的生物标志物。
