Department of Gastroenterological Surgery, National Hospital Organization, Kyushu Cancer Center.
Department of Advanced Medicine and Innovative Technology, Kyushu University Hospital, Kyushu University.
Surg Laparosc Endosc Percutan Tech. 2021 Mar 17;31(6):778-781. doi: 10.1097/SLE.0000000000000929.
In laparoscopic gastrointestinal surgery, the location of the tumor is identified mainly with marking methods, such as ink tattooing and intraoperative gastrointestinal endoscopy and marking with a metal clip followed by confirmation with intraoperative x-ray fluoroscopy. Each method has disadvantages, such as complexity, instability of ink sticks, and radiation exposure. Thus, a simple and less-invasive marking method is needed.
We developed a wireless light-emitting marker with a miniature light-emitting diode that uses a magnetic field resonance mechanism. It emits 4 individual colors-red, blue, green, and white. We confirmed the usefulness of this marker system in ex vivo and in vivo animal experiments.
In the ex vivo experiment in porcine intestines, use of the wireless marker was successful, as each color of emitted light was recognized from outside the intestine. In the live animal experiment, it was confirmed that the light emitted by the marker system was visible in the porcine intestinal tract during laparoscopic surgery. The light emitted by the wireless marker in the intestinal tract was confirmed with a laparoscope in a simulated animal surgery.
We have developed an innovative, radiation-free and reliable light-emitting marker system that uses a magnetic field resonance mechanism that emits four colors of light during laparoscopic surgery.
在腹腔镜胃肠手术中,肿瘤的位置主要通过标记方法来确定,如墨汁纹身、术中胃肠内窥镜检查和金属夹标记,然后通过术中 X 射线荧光透视来确认。每种方法都有缺点,如操作复杂、墨汁不稳定、辐射暴露等。因此,需要一种简单、微创的标记方法。
我们开发了一种带有微型发光二极管的无线发光标记物,它使用磁场共振机制。它发出 4 种颜色——红、蓝、绿和白。我们在离体和体内动物实验中验证了这种标记系统的有用性。
在猪肠的离体实验中,成功使用了无线标记物,因为从肠外可以识别出每种颜色的发光。在活体动物实验中,确认在腹腔镜手术中可以看到标记系统发出的光。在模拟动物手术中,使用腹腔镜确认了肠道内无线标记物发出的光。
我们开发了一种创新的、无辐射的、可靠的发光标记系统,该系统使用磁场共振机制,在腹腔镜手术中发出四种颜色的光。