Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Head Neck. 2021 Jul;43(7):2081-2090. doi: 10.1002/hed.26672. Epub 2021 Mar 18.
The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.
All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.
The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.
Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.
本研究旨在确定影响腮腺癌患者复发风险的预后因素，并检验三种用于预测腮腺癌患者复发风险的预后评分模型。
本研究纳入了 1990 年至 2015 年期间丹麦所有接受根治性治疗的腮腺癌患者（n=726）。采用 Cox 回归和竞争风险分析评估潜在的预后因素。采用 Harrell's C 指数评估每个预后模型的一致性。
研究人群中 344 名男性和 382 名女性，中位年龄为 63 岁。年龄>60 岁、高级别组织学、T3/T4 肿瘤、区域淋巴结转移和手术切缘受侵均与无复发生存率显著降低相关。与实际结果最吻合的预后评分模型的 C 指数为 0.76。
预后评分模型可改善腮腺癌患者接受根治性治疗后的个体化随访策略。
