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SARS-CoV-2 失控传播下的重症监护需求。

Critical Care Requirements Under Uncontrolled Transmission of SARS-CoV-2.

机构信息

Gonzalo Martínez-Alés is with the Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY. Arce Domingo-Relloso is with the National Center of Epidemiology, Carlos III Health Institute, Madrid, Spain, and the Department of Environmental Health Sciences, Columbia University Mailman School of Public Health. José R. Arribas and Manuel Quintana-Díaz are with the Instituto de Investigación Hospital Universitario, La Paz University Hospital, Madrid, Spain. Manuel Quintana-Díaz is also with the Universidad Autónoma de Madrid School of Medicine, Madrid, Spain. Miguel A. Hernán is with the Departments of Epidemiology and Biostatics, Harvard T.H. Chan School of Public Health, Harvard-MIT Division of Health Sciences and Technology, Boston, MA.

出版信息

Am J Public Health. 2021 May;111(5):923-926. doi: 10.2105/AJPH.2020.306151. Epub 2021 Mar 18.

Abstract

To estimate the critical care bed capacity that would be required to admit all critical COVID-19 cases in a setting of unchecked SARS-CoV-2 transmission, both with and without elderly-specific protection measures. Using electronic health records of all 2432 COVID-19 patients hospitalized in a large hospital in Madrid, Spain, between February 28 and April 23, 2020, we estimated the number of critical care beds needed to admit all critical care patients. To mimic a hypothetical intervention that halves SARS-CoV-2 infections among the elderly, we randomly excluded 50% of patients aged 65 years and older. Critical care requirements peaked at 49 beds per 100 000 on April 1-2 weeks after the start of a national lockdown. After randomly excluding 50% of elderly patients, the estimated peak was 39 beds per 100 000. Under unchecked SARS-CoV-2 transmission, peak critical care requirements in Madrid were at least fivefold higher than prepandemic capacity. Under a hypothetical intervention that halves infections among the elderly, critical care peak requirements would have exceeded the prepandemic capacity of most high-income countries. Pandemic control strategies that rely exclusively on protecting the elderly are likely to overwhelm health care systems.

摘要

为了估计在 SARS-CoV-2 传播不受控制的情况下,需要多少重症监护床位才能收治所有重症 COVID-19 病例,包括有无针对老年人的特定保护措施。我们使用西班牙马德里一家大型医院 2020 年 2 月 28 日至 4 月 23 日期间所有 2432 例 COVID-19 住院患者的电子健康记录,估计了收治所有重症监护患者所需的重症监护床位数量。为了模拟一种假设的干预措施,可以使老年人中 SARS-CoV-2 感染减少一半,我们随机排除了 50%的 65 岁及以上患者。重症监护需求在 4 月 1 日至 2 周后达到高峰,每 10 万人中有 49 张床位。随机排除 50%的老年患者后,估计的高峰为每 10 万人中有 39 张床位。在 SARS-CoV-2 不受控制的传播情况下,马德里的重症监护需求高峰至少是大流行前容量的五倍。在一种假设的干预措施下,该措施使老年人的感染减少一半,重症监护需求高峰将超过大多数高收入国家大流行前的容量。仅依靠保护老年人的大流行控制策略可能会使医疗系统不堪重负。

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