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糖尿病视网膜病变进展的生物标志物:通过人工智能与电子健康记录的整合拓展个性化医疗。

Biomarkers for Progression in Diabetic Retinopathy: Expanding Personalized Medicine through Integration of AI with Electronic Health Records.

机构信息

Joslin Diabetes Centre, Beetham Eye Institute, Boston, MA, USA.

Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

出版信息

Semin Ophthalmol. 2021 May 19;36(4):250-257. doi: 10.1080/08820538.2021.1893351. Epub 2021 Mar 18.

DOI:10.1080/08820538.2021.1893351
PMID:33734908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8122081/
Abstract

The goal of personalized diabetes eye care is to accurately predict in real-time the risk of diabetic retinopathy (DR) progression and visual loss. The use of electronic health records (EHR) provides a platform for artificial intelligence (AI) algorithms that predict DR progression to be incorporated into clinical decision-making. By implementing an algorithm on data points from each patient, their risk for retinopathy progression and visual loss can be modeled, allowing them to receive timely treatment. Data can guide algorithms to create models for disease and treatment that may pave the way for more personalized care. Currently, there exist numerous challenges that need to be addressed before reliably building and deploying AI algorithms, including issues with data quality, privacy, intellectual property, and informed consent.

摘要

个性化糖尿病眼病护理的目标是实时准确预测糖尿病视网膜病变(DR)进展和视力丧失的风险。电子健康记录(EHR)的使用为人工智能(AI)算法提供了一个平台,这些算法可以预测 DR 的进展并纳入临床决策。通过在每位患者的数据点上实施算法,可以对其视网膜病变进展和视力丧失的风险进行建模,从而使他们能够及时得到治疗。数据可以指导算法为疾病和治疗创建模型,从而为更个性化的护理铺平道路。目前,在可靠地构建和部署 AI 算法之前,还需要解决许多挑战,包括数据质量、隐私、知识产权和知情同意等问题。

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本文引用的文献

1
Applications of Artificial Intelligence to Electronic Health Record Data in Ophthalmology.人工智能在眼科学电子病历数据中的应用。
Transl Vis Sci Technol. 2020 Feb 27;9(2):13. doi: 10.1167/tvst.9.2.13.
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Simple, Mobile-based Artificial Intelligence Algoithm in the detection of Diabetic Retinopathy (SMART) study.基于移动设备的糖尿病视网膜病变检测简易人工智能算法(SMART)研究
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Predicting optical coherence tomography-derived diabetic macular edema grades from fundus photographs using deep learning.利用深度学习技术从眼底照片预测光学相干断层扫描糖尿病黄斑水肿分级。
Nat Commun. 2020 Jan 8;11(1):130. doi: 10.1038/s41467-019-13922-8.
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NPJ Digit Med. 2019 Sep 20;2:92. doi: 10.1038/s41746-019-0172-3. eCollection 2019.
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Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9 edition.2019 年全球及各区域糖尿病患病率估算值及 2030 年和 2045 年预测值:国际糖尿病联盟糖尿病地图集(第 9 版)的结果。
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Artificial Intelligence Screening for Diabetic Retinopathy: the Real-World Emerging Application.人工智能在糖尿病视网膜病变筛查中的应用:真实世界中的新兴应用。
Curr Diab Rep. 2019 Jul 31;19(9):72. doi: 10.1007/s11892-019-1189-3.
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The Value of Automated Diabetic Retinopathy Screening with the EyeArt System: A Study of More Than 100,000 Consecutive Encounters from People with Diabetes.EyeArt 系统自动化糖尿病视网膜病变筛查的价值:一项涉及超过 10 万名糖尿病患者连续就诊的研究。
Diabetes Technol Ther. 2019 Nov;21(11):635-643. doi: 10.1089/dia.2019.0164. Epub 2019 Aug 7.
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Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices.在基层医疗诊所中用于检测糖尿病视网膜病变的基于人工智能的自主诊断系统的关键试验。
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