Katz A H, Demerson C A, Shaw C C, Asselin A A, Humber L G, Conway K M, Gavin G, Guinosso C, Jensen N P, Mobilio D
Ayerst Laboratories Research, Inc., Princeton, New Jersey 08543-8000.
J Med Chem. 1988 Jun;31(6):1244-50. doi: 10.1021/jm00401a029.
The synthesis of cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole -1-acetic acid, pemedolac (USAN), is described. This compound has been found to be a potent analgesic agent in primary screening. Pemedolac has been resolved and the active (+)-enantiomer assigned a 1S,4R absolute configuration on the basis of a crystallographic analysis of its (S)-(-)-borneol ester.
描述了顺式-1-乙基-1,3,4,9-四氢-4-(苯甲基)吡喃并[3,4-b]吲哚-1-乙酸（培美拉酸，USAN）的合成。该化合物在初步筛选中已被发现是一种强效镇痛剂。培美拉酸已被拆分，并且基于其(S)-(-)-冰片酯的晶体学分析，活性(+)-对映体被指定为1S,4R绝对构型。
