Du Ke, Bereswill Stefan, Heimesaat Markus M
Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Eur J Microbiol Immunol (Bp). 2021 Mar 17;11(1):1-9. doi: 10.1556/1886.2021.00001.
The excessive prescription of antibiotics has led to an increasing number of antimicrobial resistances, posing a major public health concern. Therefore, the pharmacological research has shifted its focus to the identification of natural compounds that exhibit anti-pathogenic properties without triggering antibiotic resistance. Butyrate has received increasing attention as a promising candidate for the treatment of bacterial infections in the gastrointestinal tract, particularly when antibiotic treatment is contraindicated. This literature survey summarizes recently investigated antibacterial and immune-modulatory effects of butyrate. This survey revealed that butyrate exerts direct antimicrobial effects against distinct strains of Acinetobacter baumannii, Escherichia coli, Bacillus, and Staphylococcus species. In addition, in vitro and in vivo studies confirmed indirect antimicrobial effects of butyrate, which were exhibited via induction of host defensin production as well as by activation of innate and adaptive immune responses. Finally, the synergistic action of butyrate in combination with other antimicrobial compounds results in a striking clearance of bacterial pathogens. In conclusion, butyrate and its derivatives might be considered as promising antibacterial and immune-modulatory agents in order to tackle bacterial infections without antibiotics.
抗生素的过度使用导致了越来越多的抗菌耐药性，这成为一个重大的公共卫生问题。因此，药理学研究已将重点转向鉴定具有抗病原体特性且不会引发抗生素耐药性的天然化合物。丁酸盐作为治疗胃肠道细菌感染的有前景的候选物受到了越来越多的关注，尤其是在抗生素治疗禁忌的情况下。本文献综述总结了最近对丁酸盐抗菌和免疫调节作用的研究。该综述表明，丁酸盐对鲍曼不动杆菌、大肠杆菌、芽孢杆菌和葡萄球菌等不同菌株具有直接抗菌作用。此外，体外和体内研究证实了丁酸盐的间接抗菌作用，这是通过诱导宿主防御素产生以及激活先天性和适应性免疫反应来实现的。最后，丁酸盐与其他抗菌化合物的协同作用可显著清除细菌病原体。总之，丁酸盐及其衍生物可能被视为有前景的抗菌和免疫调节药物，以便在不使用抗生素的情况下应对细菌感染。
