Bakal Seher Nancy, Bereswill Stefan, Heimesaat Markus M
Department of Microbiology and Hygiene, Charité - University Medicine Berlin , Berlin, Germany.
Eur J Microbiol Immunol (Bp). 2017 Mar 16;7(1):92-98. doi: 10.1556/1886.2017.00001. eCollection 2017 Mar.
The progressive rise in multidrug-resistant (MDR) bacterial strains poses serious problems in the treatment of infectious diseases. While the number of newly developed antimicrobial compounds has greatly fallen, the resistance of pathogens against commonly prescribed drugs is further increasing. This rise in resistance illustrates the need for developing novel therapeutic and preventive antimicrobial options. The medicinal herb and its derivatives constitute promising candidates. In a comprehensive literature survey (using the PubMed data base), we searched for publications on the antimicrobial effects of particularly directed against MDR bacterial strains. studies published between 2000 and 2015 revealed that exerted potent antibacterial effects against both Gram-positive and Gram-negative species including resistant strains. For instance, inhibited the growth of bacteria causing significant gastrointestinal morbidity such as , and . However, and displayed resistance against black cumin seed extracts. In conclusion, our literature survey revealed potent antimicrobial properties of against MDR strains that should be further investigated in order to develop novel therapeutic perspectives for combating infectious diseases particularly caused by MDR strains.
多重耐药（MDR）细菌菌株的不断增加给传染病治疗带来了严重问题。虽然新开发的抗菌化合物数量大幅下降，但病原体对常用药物的耐药性却在进一步增强。这种耐药性的增加表明需要开发新的治疗和预防性抗菌方法。药草及其衍生物是很有前景的候选物。在一项全面的文献调查（使用PubMed数据库）中，我们搜索了关于特别是针对MDR细菌菌株的抗菌作用的出版物。2000年至2015年间发表的研究表明，对革兰氏阳性和革兰氏阴性菌包括耐药菌株都具有强大的抗菌作用。例如，抑制了引起严重胃肠道疾病的细菌如、和的生长。然而，和对黑孜然籽提取物表现出耐药性。总之，我们的文献调查揭示了对MDR菌株具有强大的抗菌特性，为了开发对抗特别是由MDR菌株引起的传染病的新治疗前景，应该进一步研究。
