Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, San Diego, California, United States of America.
Institute for Global Health Sciences, University of California, San Francisco, California, United States of America.
PLoS One. 2021 Mar 18;16(3):e0247260. doi: 10.1371/journal.pone.0247260. eCollection 2021.
Maternal and neonatal mortality in Bihar, India was far higher than the aspirational levels set out by the Sustainable Development Goals. Provider training programs have been implemented in many low-resource settings to improve obstetric and neonatal outcomes. This longitudinal investigation assessed diagnoses and management of postpartum hemorrhage (PPH), hypertensive disorders of pregnancy, birth asphyxia (BA), and low birth weight (LBW), as part of the CARE's AMANAT program in 22 District Hospitals in Bihar, between 2015 and 2017. Physicians and nurse mentors conducted clinical instruction, simulations and teamwork and communication activities, infrastructure and management support, and data collection for 6 consecutive months. Analysis of diagnosis included 11,259 non-referred and management included 11,800 total (non-referred and referred) admissions that were observed. Data were analyzed using the chi-square test for trend. PPH was diagnosed in 3.7% with no significant trend but diagnosis of hypertensive disorders increased from 1.0% to 1.7%, (ptrend = 0.04), over the 6 months. BA was diagnosed in 5.8% with no significant trend but LBW diagnoses increased from 11% to 16% (ptrend<0.01). Among PPH patients, 96% received fluids, 85% received uterotonics and 11% received Tranexamic Acid (TXA). There was a significant positive trend in the number of patients receiving TXA for PPH (6% to 13.8%, ptrend = 0.03). Of all neonates with BA, there were statistically significant increases in the proportion who were initially warmed, dried, and stimulated (78% to 94%, ptrend = 0.02), received airway suction (80% to 93%, ptrend = 0.03), and supplemental oxygen without positive pressure ventilation (73% to 86%, ptrend = 0.05). Diagnoses of hypertensive disorders and LBW as well as initial management of BA increased during the AMANAT program. However, underdiagnoses of PPH and hypertensive disorders relative to population levels remain critical barriers to improving maternal morbidity and mortality.
印度比哈尔邦的母婴死亡率远高于可持续发展目标设定的理想水平。为了改善产科和新生儿结局,许多资源匮乏的环境都实施了提供者培训计划。本纵向研究评估了 2015 年至 2017 年 CARE 的 AMANAT 项目在比哈尔邦 22 家地区医院中产后出血 (PPH)、妊娠高血压疾病、出生窒息 (BA) 和低出生体重 (LBW) 的诊断和管理,医生和护士导师进行了临床指导、模拟和团队合作与沟通活动、基础设施和管理支持以及为期 6 个月的连续数据收集。分析包括对 11259 例非转诊和 11800 例(非转诊和转诊)总例数的诊断,使用卡方检验进行趋势分析。PPH 的诊断率为 3.7%,无显著趋势,但高血压疾病的诊断从 1.0%增加到 1.7%(ptrend=0.04),6 个月期间呈上升趋势。BA 的诊断率为 5.8%,无显著趋势,但 LBW 的诊断从 11%增加到 16%(ptrend<0.01)。在 PPH 患者中,96%接受补液,85%接受宫缩剂,11%接受氨甲环酸(TXA)。接受 TXA 治疗 PPH 的患者数量呈显著正趋势(6%至 13.8%,ptrend=0.03)。所有 BA 新生儿中,最初接受加热、干燥和刺激(78%至 94%,ptrend=0.02)、接受气道抽吸(80%至 93%,ptrend=0.03)和补充氧而无需正压通气(73%至 86%,ptrend=0.05)的比例均有统计学意义的增加。在 AMANAT 项目期间,高血压疾病和 LBW 的诊断以及 BA 的初始管理有所增加。然而,PPH 和高血压疾病的漏诊率相对于人群水平仍然是降低孕产妇发病率和死亡率的关键障碍。