早期创伤与惊恐障碍患者药物治疗反应不佳有关。
Early Trauma Is Associated with Poor Pharmacological Treatment Response in Patients with Panic Disorder.
作者信息
Kim Hyun-Ju, Kim Ji Eun, Lee Sang-Hyuk
机构信息
Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
Graduate School of Social Welfare, Yonsei University, Seoul, Republic of Korea.
出版信息
Psychiatry Investig. 2021 Mar;18(3):249-256. doi: 10.30773/pi.2020.0380. Epub 2021 Mar 19.
OBJECTIVE
Pharmacotherapy is established as an effective method for reducing symptoms of panic disorder (PD). However, about 20-40% of PD patients are treatment-resistant. Predictors of pharmacotherapy outcomes for PD patients are needed.
METHODS
This study included 152 PD patients to measure the clinical severities of PD symptoms and used the Early Trauma Inventory (ETI) to measure early trauma. Treatment response was defined as a 40% reduction in the total Panic Disorder Severity Scale score from baseline. We measured the treatment responses at 8 weeks and 6 months. Binary logistic regression was used to predict treatment response after controlling for confounding variables.
RESULTS
Early sexual trauma alone was associated with poor treatment response at 8 weeks. However, at 6 months, the total ETI score was associated with an unfavorable treatment response.
CONCLUSION
Therefore, our study suggests that clinicians need to be aware of a history of early trauma to optimize treatment outcomes for PD patients.
目的
药物治疗已被确立为减轻惊恐障碍（PD）症状的有效方法。然而，约20%-40%的PD患者对治疗耐药。需要确定PD患者药物治疗结果的预测因素。
方法
本研究纳入152例PD患者，以测量PD症状的临床严重程度，并使用早期创伤量表（ETI）测量早期创伤。治疗反应定义为惊恐障碍严重程度量表总分较基线降低40%。我们在8周和6个月时测量治疗反应。在控制混杂变量后，采用二元逻辑回归预测治疗反应。
结果
仅早期性创伤与8周时的治疗反应不佳相关。然而，在6个月时，ETI总分与不良治疗反应相关。
结论
因此，我们的研究表明，临床医生需要了解早期创伤史，以优化PD患者的治疗结果。
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