Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Comp Immunol Microbiol Infect Dis. 2021 Jun;76:101642. doi: 10.1016/j.cimid.2021.101642. Epub 2021 Mar 11.
Bovine babesiosis due to Babesia bigemina infection induces systemic inflammation, evidenced by increased sialic acid (SA) levels and declined cholinesterase activity. The current study was undertaken to assess further indicators of the systemic inflammation in the naturally infected cattle. To this end, serum levels of some selected acute phase-proteins (APPs) including serum amyloid A (SAA), haptoglobin (Hp), ceruloplasmin (Cp), and fibrinogen were measured. Additionally, sensitivity and specificity of the APPs were calculated by receiver operating characteristic curve. The correlation among APPs, SA and cholinesterase activity were also assessed. Our previous blood specimens were used to measure APPs. Briefly, the diseased animals were divided into two groups according to the parasitemia: 12 mildly (20 % <) and 8 severely (20 %>) infected animals. Moreover, 10 healthy animals as the control were included. The levels of all APPs were measured to be significantly elevated in a parasitemia burden-dependent fashion as compared to the control. Furthermore, all the APPs showed 100 % specificity, but only SAA and Cp had 100 % sensitivity. A strong and positive correlation was calculated between the APPs and SA; however, cholinesterase activity was inversely correlated with AAPs and SA. In conclusion, inflammatory reactions play a pivotal role in the pathogenesis of bovine babesiosis and APPs can be considered as the potential indicators of inflammation.
牛巴贝斯虫感染引起的巴贝斯虫病会导致全身性炎症，这表现在唾液酸（SA）水平升高和胆碱酯酶活性下降。本研究旨在评估自然感染牛的全身性炎症的进一步指标。为此，测量了一些选定的急性期蛋白（APPs）的血清水平，包括血清淀粉样蛋白 A（SAA）、触珠蛋白（Hp）、铜蓝蛋白（Cp）和纤维蛋白原。此外，还通过接收者操作特征曲线计算了 APPs 的敏感性和特异性。还评估了 APPs、SA 和胆碱酯酶活性之间的相关性。我们之前的血液样本用于测量 APPs。简而言之，根据寄生虫血症将患病动物分为两组：12 只轻度（20%<）和 8 只重度（20%>）感染动物。此外，还包括 10 只健康动物作为对照。与对照组相比，所有 APPs 的水平均呈寄生虫血症负担依赖性显著升高。此外，所有 APPs 的特异性均为 100%，但只有 SAA 和 Cp 的敏感性为 100%。APPs 与 SA 之间存在强烈的正相关；然而，胆碱酯酶活性与 AAPs 和 SA 呈负相关。总之，炎症反应在牛巴贝斯虫病的发病机制中起着关键作用，APPs 可以被认为是炎症的潜在指标。
