分析意大利 SARS-CoV-2 毒株中的 3 种突变：对发病机制的影响。
Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis.
机构信息
Medical Statistic and Molecular Epidemiology Unit, Campus Bio-Medico University, Rome, Italy.
Institute of Human Virology and Global Virus Network Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
出版信息
Chemotherapy. 2021;66(1-2):33-37. doi: 10.1159/000515342. Epub 2021 Mar 18.
BACKGROUND
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths.
OBJECTIVE
As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy.
METHODS
DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID.
RESULTS
In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein.
CONCLUSION
The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.
背景
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是一种包膜病毒，最初于 2019 年 12 月在武汉被发现，可引发 2019 年冠状病毒病（COVID-19），这是一种呼吸道综合征，目前在全球 220 多个国家流行，已登记超过 8000 万例病例，死亡人数超过 180 万。
目的
由于目前仍在开发几种疫苗，并且已经批准了两种疫苗，因此进行进化监测以识别可能影响疫苗效果的突变尤为重要。
方法
使用 DynaMut 服务器评估 GISAID 上提供的 SARS-CoV-2 分离株中发现的突变的影响。
结果
本文分析了来自意大利患者的全基因组序列，并报告了 3 种突变的特征，其中一种发生在刺突蛋白上。
结论
本文分析的突变可以有助于评估 SARS-CoV-2 的进化。
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