Foreyt W J, Evermann J F
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
J Wildl Dis. 1988 Apr;24(2):356-9. doi: 10.7589/0090-3558-24.2.356.
Five Rocky Mountain bighorn sheep (Ovis canadensis canadensis), approximately 5 mo old and without detectable antibody titers to respiratory syncytial virus (RSV), were assigned to two groups to study the effects of RSV challenge inoculation in vaccinated (n = 3) and unvaccinated (n = 2) bighorns. The three lambs vaccinated with a modified live bovine RSV vaccine developed a detectable antibody response to the vaccine. Vaccinated and unvaccinated lambs challenged with an ovine isolate of RSV developed increased levels of neutralizing antibody, but clinical signs of disease were not observed. Neutralizing antibody titers to RSV remained higher (2-4-fold) in vaccinated lambs over time when compared to unvaccinated lambs.
五只落基山大角羊（加拿大盘羊指名亚种），约5月龄，对呼吸道合胞病毒（RSV）无可检测到的抗体滴度，被分为两组，以研究RSV攻击接种对已接种疫苗（n = 3）和未接种疫苗（n = 2）的大角羊的影响。三只接种了改良活牛RSV疫苗的羔羊对该疫苗产生了可检测到的抗体反应。用绵羊分离株RSV攻击接种的已接种疫苗和未接种疫苗的羔羊，其中和抗体水平升高，但未观察到疾病的临床症状。与未接种疫苗的羔羊相比，接种疫苗的羔羊体内RSV的中和抗体滴度随时间保持较高水平（2至4倍）。
