Usman Mohammed Aliyu, Usman Fadilat Isah, Abubakar Muhammad Sani, Salman Abdulmalik Abdullahi, Adamu Auwal, Ibrahim Mohammed Auwal
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Exp Parasitol. 2021 May;224:108097. doi: 10.1016/j.exppara.2021.108097. Epub 2021 Mar 15.
The quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium falciparum under in vitro condition. On this basis, the in vivo anti-Plasmodium berghei activity of phytol including the ameliorative effects of the compound on P. berghei-associated anaemia and organ damage were investigated. Mice were infected with chloroquine-sensitive strain of P. berghei and were treated with phytol at a dose of 10 and 20 mg/kg body weight (BW) for four days. The levels of parasitemia, packed cell volume and redox sensitive biomarkers of liver, brain and spleen tissues were determined. Our result revealed that phytol significantly (p < 0.05) suppressed the multiplication of P. berghei in a dose-dependent manner. Additionally, the phytol significantly (p < 0.05) ameliorated the P. berghei-induced anaemia and brain damage. Data from the present study demonstrated that phytol has suppressive effect on P. berghei and could ameliorate some P. berghei-induced pathological changes.
在体外条件下证明了植物醇对氯喹敏感的恶性疟原虫菌株具有治疗潜力后，为开发新型抗疟药物而决定对植物醇进行体内试验。在此基础上，研究了植物醇对伯氏疟原虫的体内抗疟活性，包括该化合物对伯氏疟原虫相关贫血和器官损伤的改善作用。用氯喹敏感的伯氏疟原虫菌株感染小鼠，并用剂量为10和20毫克/千克体重的植物醇处理四天。测定了疟原虫血症水平、红细胞压积以及肝脏、大脑和脾脏组织中对氧化还原敏感的生物标志物。我们的结果显示，植物醇以剂量依赖性方式显著（p<0.05）抑制伯氏疟原虫的增殖。此外，植物醇显著（p<0.05）改善了伯氏疟原虫引起的贫血和脑损伤。本研究数据表明，植物醇对伯氏疟原虫具有抑制作用，并可改善一些伯氏疟原虫引起的病理变化。
