线粒体疾病中的低血糖症。

Hypoglycemia in mitochondrial disorders.

作者信息

Ashfaq Myla, Moats Allison R, Northrup Hope, Singletary Claire N, Hashmi S Shahrukh, Koenig Mary Kay, Bagg Michael B, Rodriguez-Buritica David

机构信息

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

出版信息

Mitochondrion. 2021 May;58:179-183. doi: 10.1016/j.mito.2021.03.002. Epub 2021 Mar 16.

DOI:10.1016/j.mito.2021.03.002

PMID:33737013

Abstract

Diabetes and hyperglycemia are common features of mitochondrial disorders. This study investigates the frequency of non-iatrogenic hypoglycemia in individuals with these disorders. Of 116 patients, 22 (18.97%) experienced at least two episodes of hypoglycemia. This rate is significantly higher (p < 0.05) than the 6% seen in the non-diabetic, general population. Neonatal readings were 30 mg/dL lower than non-neonatal readings. As hypoglycemia appears to occur frequently in individuals with mitochondrial disorders, with lower blood glucose levels in the neonatal period, early and continued monitoring of blood glucose is necessary. Also, mitochondrial disorders should be considered in cases of recurrent hypoglycemia.

摘要

糖尿病和高血糖是线粒体疾病的常见特征。本研究调查了患有这些疾病的个体中非医源性低血糖的发生率。在116名患者中，22名（18.97%）经历了至少两次低血糖发作。这一发生率显著高于非糖尿病普通人群中的6%（p < 0.05）。新生儿期的血糖读数比非新生儿期低30mg/dL。由于线粒体疾病患者似乎经常发生低血糖，且新生儿期血糖水平较低，因此有必要早期并持续监测血糖。此外，对于反复发生低血糖的病例，应考虑线粒体疾病。