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Darier 病患者的眼科评估。

Ophthalmic Assessment in Patients With Darier Disease.

机构信息

From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Dermatology, Emek Medical Center, Afula, Israel (H.H., A.Y., M.Z., R.P.D.-G.).

From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Ophthalmology, Emek Medical Center, Afula, Israel (L.A.).

出版信息

Am J Ophthalmol. 2021 Jul;227:139-142. doi: 10.1016/j.ajo.2021.03.011. Epub 2021 Mar 15.

Abstract

PURPOSE

To assess the prevalence of ophthalmic findings in patients with Darier disease, an autosomal dominant genetic skin disorder, in an effort to evaluate the need for eye examinations in the management of the disease.

DESIGN

Prospective observational case series.

METHODS

Thirty-six individuals with Darier disease were evaluated by both ocular assessment questionnaire and a comprehensive ophthalmic examination (visual acuity, refraction, external examination, and slit-lamp examination) with emphasis on the eyelids, conjunctiva, and cornea. In addition, questionnaire-based medical interview and skin examination were conducted.

RESULTS

According to the medical questionnaire, 39% of patients reported eye problems, 36% dry eye, and 42% eye fatigue after prolonged reading. Ocular examination revealed Darier disease lesions on the eyelids in 55% of the patients, blepharitis in 44%, conjunctival hyperemia in 28%, and short tear film break-up time in 83%. There was no significant relationship between any of these ophthalmic findings and systemic retinoid therapy, sex, or age.

CONCLUSIONS

The high prevalence of blepharitis and dry eye highlights the importance of ophthalmologic evaluation of patients with Darier disease.

摘要

目的

评估 Darier 病(一种常染色体显性遗传的皮肤疾病)患者眼部疾病的患病率,以便评估在该疾病的管理中进行眼部检查的必要性。

设计

前瞻性观察性病例系列研究。

方法

通过眼部评估问卷和全面的眼科检查(视力、屈光、眼部外部检查和裂隙灯检查)对 36 名 Darier 病患者进行评估,重点关注眼睑、结膜和角膜。此外,还进行了基于问卷调查的医学访谈和皮肤检查。

结果

根据医学问卷,39%的患者报告有眼部问题,36%的患者有干眼症,42%的患者在长时间阅读后眼睛疲劳。眼部检查发现 55%的患者眼睑有 Darier 病病变,44%的患者患有睑缘炎,28%的患者结膜充血,83%的患者泪膜破裂时间短。这些眼部表现与全身类视黄醇治疗、性别或年龄均无显著关系。

结论

睑缘炎和干眼症的高患病率突出了对 Darier 病患者进行眼科评估的重要性。

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