Department of Oncology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, Fujian, China.
Gene. 2021 Jun 5;784:145575. doi: 10.1016/j.gene.2021.145575. Epub 2021 Mar 16.
Filamin A(FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion and migration. It is involved in signal transduction, cell proliferation and differentiation, pseudopodia formation, vesicle transport, tumor resistance and genetic diseases by binding with interacting proteins. In order to fully elucidate the structure, function and pathogenesis of FLNa, we summarized all substances which directly or indirectly act on FLNa so far, upstream and downstream targets which having effect on it, signaling pathways and their functions. It also recorded the expression and effect of FLNa in different diseases, including hereditary disease and tumors.
细丝蛋白 A（FLNa）是一种肌动蛋白结合蛋白，参与细胞骨架的形成，将多种蛋白质锚定在细胞骨架上，并调节细胞黏附和迁移。它通过与相互作用蛋白结合参与信号转导、细胞增殖和分化、伪足形成、囊泡运输、肿瘤耐药和遗传性疾病。为了充分阐明 FLNa 的结构、功能和发病机制，我们总结了迄今为止直接或间接作用于 FLNa 的所有物质、对其有影响的上下游靶点、信号通路及其功能。还记录了 FLNa 在不同疾病中的表达和作用，包括遗传性疾病和肿瘤。
