Mori A, Watanabe K, Onoe M, Watarida S, Nakamura Y, Magara T, Tabata R, Okada Y
Second Department of Surgery, Shiga University of Medical Science, Japan.
Jpn Circ J. 1988 Mar;52(3):219-27. doi: 10.1253/jcj.52.219.
Regional blood flow in the liver, pancreas and kidney was measured under conditions of profound hypothermia associated with total circulatory arrest, to determine whether cardiopulmonary bypass with pulsatile flow would improve the blood flow in these visceral organs in comparison with nonpulsatile flow. Using 56 adult mongrel dogs, total cardiopulmonary bypass was carried out to induce hypothermia and 40 min of total circulatory arrest was performed at 20 degrees C. After total arrest, the temperature was raised to 35 degrees C. With pulsatile flow, a decrease of the regional blood flow in the liver, pancreas and kidney was prevented during cooling, especially at 20 degrees C before total circulatory arrest. Moreover, regional renal blood flow recovered rapidly with pulsatile flow after total arrest at 20 degrees C, while after arrest with nonpulsatile flow blood flow in the kidney could not be measured in the cortex and was significantly lower in the medulla. In summary, pulsatile flow improves the hepatic, pancreatic and renal blood flow and, referring to our previous experiments, protects the function of these organs during cardiopulmonary bypass associated with profound hypothermia and total circulatory arrest.
在与完全循环停止相关的深度低温条件下，测量肝脏、胰腺和肾脏的局部血流量，以确定与非搏动性血流相比，搏动性血流的体外循环是否能改善这些内脏器官的血流量。使用56只成年杂种犬，进行全身体外循环以诱导低温，并在20℃下进行40分钟的完全循环停止。完全停止后，将温度升至35℃。使用搏动性血流时，在降温过程中，尤其是在完全循环停止前的20℃时，肝脏、胰腺和肾脏的局部血流量减少得到了预防。此外，在20℃完全停止后，搏动性血流使局部肾血流量迅速恢复，而非搏动性血流停止后，肾皮质血流量无法测量，髓质血流量显著降低。总之，搏动性血流可改善肝脏、胰腺和肾脏的血流量，参照我们之前的实验，在与深度低温和完全循环停止相关的体外循环过程中，搏动性血流可保护这些器官的功能。
