Department of Dermatology, University Clinical Hospital of Santiago de Compostela, Spain.
Department of Dermatology, University Clinical Hospital of Santiago de Compostela, Spain.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102258. doi: 10.1016/j.pdpdt.2021.102258. Epub 2021 Mar 15.
Sweet's syndrome is a neutrophilic dermatosis associated with many different underlying conditions but only rarely is it triggered by environmental factors such as ultraviolet (UV) exposure. We present two cases of photoinduced Sweet syndrome. Our first patient, who was taking hydrochlorothiazide, presented photodistributed lesions, pathological phototest and neutrophilic dermatosis histopathology. The phototest normalized after drug withdrawal, suggesting that both UV light and hydrochlorothiazide were necessary to cause the lesions. Our second case presented lesions clearly induced by UV light and histologically consistent with Sweet's syndrome. The MED was decreased and the lesions were reproduced with nbUVB, suggesting the diagnosis of photoinduced Sweet's syndrome. In conclusion, we report a case of neutrophilic dermatosis induced by hydrochlorothiazide and UV light and a case of photoinduced Sweet's syndrome with reproduction of the lesions after nbUVB. Both patients had a pathologic photobiological study. Our report emphasizes the need to perform phototests in patients with photodistributed Sweet's syndrome.
Sweet 综合征是一种与许多不同潜在疾病相关的中性粒细胞皮肤病，但它仅偶尔由环境因素如紫外线 (UV) 暴露引发。我们报告两例光诱导的 Sweet 综合征。我们的第一位患者正在服用氢氯噻嗪，表现为光分布的病变、病理光试验和中性粒细胞皮肤病组织病理学。药物停用后光试验恢复正常，表明 UV 光和氢氯噻嗪均是导致病变所必需的。我们的第二位病例表现出明确由 UV 光诱导的病变，组织学上与 Sweet 综合征一致。MED 降低，nbUVB 重现病变，提示光诱导的 Sweet 综合征的诊断。总之，我们报告了一例由氢氯噻嗪和 UV 光引起的中性粒细胞皮肤病和一例光诱导的 Sweet 综合征，nbUVB 后重现病变。两名患者均进行了病理光生物学研究。我们的报告强调了对光分布的 Sweet 综合征患者进行光试验的必要性。
