Sousa Débora, Rocha Filipa, Baptista Bernardo, Horta Alexandra Bayão
Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, PRT.
Cureus. 2021 Feb 12;13(2):e13297. doi: 10.7759/cureus.13297.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a parenchymal lung disease characterized by a proliferation of neuroendocrine cells in the bronchial wall, with possible local invasion and occasional development of tumorlets. It is considered to be a precursor lesion as it can progress to neuroendocrine tumors (NETs). At presentation, approximately one-half of patients with DIPNECH have a synchronous diagnosis of NET. Here, we present the case of a 95-year-old woman with progressive exertional dyspnea. She was found to have an obstructive airway syndrome and long-lasting progressive bilateral pulmonary nodules, with a distribution and growth pattern suggestive of DIPNECH, as well as possible progression to NET in the larger lesions. A transthoracic needle aspiration biopsy of a pulmonary nodule was performed, confirming the diagnosis of NET, evolving from DIPNECH.
弥漫性特发性肺神经内分泌细胞增生症（DIPNECH）是一种实质性肺部疾病，其特征为支气管壁神经内分泌细胞增殖，可能出现局部浸润，偶尔会发展为微瘤。它被认为是一种前驱病变，因为它可能进展为神经内分泌肿瘤（NETs）。在就诊时，约一半的DIPNECH患者同时被诊断为NET。在此，我们报告一例95岁女性患者，其有进行性劳力性呼吸困难。她被发现患有阻塞性气道综合征和长期进展性双侧肺结节，其分布和生长模式提示为DIPNECH，且较大病变可能进展为NET。对一个肺结节进行了经胸针吸活检，确诊为源自DIPNECH的NET。
