Department of Dermatology, the Third Xiangya Hospital, Central South University, Changsha, China.
Photodermatol Photoimmunol Photomed. 2021 Sep;37(5):442-448. doi: 10.1111/phpp.12679. Epub 2021 Mar 26.
Programmed cell death (PCD) is a basic component of life and an important terminal path for cells. A variety of biological events are associated with PCD, including the conservation of tissue homeostasis and removal of harmful cells. Overexposure of the skin to UV radiation causes skin photodamage. Keratinocytes are the first line of defence against ultraviolet radiation. During UV radiation, the keratinocyte can undergo four modes of PCD: apoptosis, pyroptosis, necroptosis and autophagy. The molecular mechanisms of these four modes of PCD have been widely studied as potential therapeutic targets for the prevention of UV-induced skin inflammation, ageing and skin cancer. In this review, we summarize the role of keratinocyte PCD in the pathogenesis of UV-induced skin photodamage. This article will provide new research directions for the design of intervention strategies for the treatment and prevention of skin photodamage.
程序性细胞死亡（PCD）是生命的基本组成部分，也是细胞的重要终末途径。多种生物学事件都与 PCD 相关，包括组织内稳态的维持和有害细胞的清除。皮肤过度暴露于紫外线辐射会导致皮肤光损伤。角质形成细胞是抵御紫外线辐射的第一道防线。在紫外线辐射下，角质形成细胞可经历四种 PCD 模式：细胞凋亡、细胞焦亡、坏死性凋亡和自噬。这四种 PCD 模式的分子机制已被广泛研究，作为预防紫外线引起的皮肤炎症、衰老和皮肤癌的潜在治疗靶点。本综述总结了角质形成细胞 PCD 在紫外线诱导皮肤光损伤发病机制中的作用。本文将为治疗和预防皮肤光损伤的干预策略设计提供新的研究方向。
