Li Herui, Ma Yiming, Xue Jin, He Chenjie, Zhan Zijie, Liu Xiangming, Chen Ping, Cai Shan, Zeng Yuqin, Wu Qian, Chen Yan
Clin Lab. 2021 Mar 1;67(3). doi: 10.7754/Clin.Lab.2020.200630.
This study aimed to evaluate the C-reactive protein to serum albumin ratio (CAR) to predict prognosis in COPD patients with acute exacerbations (AECOPD).
A retrospective cohort study of AECOPD patients, admitted to a large tertiary hospital between January 2017 and June 2018, was conducted. Univariate and multivariate logistic regression models were built to assess the relationship between variables and different clinical outcomes in one-year follow up. In addition, Kaplan-Meier method was used to estimate the relationship between CAR and the time to first rehospitalization due to acute exacerbation of COPD.
A total of 167 AECOPD patients were included in this study, with an overall age of 68.5 ± 9.4 years. Both univariate and multivariate logistic regression analysis demonstrated that CAR at admission was significantly associated with rehospitalization and frequent exacerbations in COPD patients (p < 0.05). Kaplan-Meier curve showed that the rehospitalization event-free rate was significantly higher in the low CAR group than the high CAR group (p < 0.01).
As an easily available parameter, CAR at admission can be an independent predictor for rehospitalization and frequent exacerbations in COPD patients with acute exacerbations.
本研究旨在评估C反应蛋白与血清白蛋白比值（CAR）对慢性阻塞性肺疾病急性加重期（AECOPD）患者预后的预测价值。
对2017年1月至2018年6月入住一家大型三级医院的AECOPD患者进行回顾性队列研究。建立单因素和多因素逻辑回归模型，以评估变量与一年随访中不同临床结局之间的关系。此外，采用Kaplan-Meier法评估CAR与因COPD急性加重首次再入院时间之间的关系。
本研究共纳入167例AECOPD患者，平均年龄为68.5±9.4岁。单因素和多因素逻辑回归分析均显示，入院时的CAR与COPD患者的再入院和频繁加重显著相关（p<0.05）。Kaplan-Meier曲线显示，低CAR组的无再入院事件发生率显著高于高CAR组（p<0.01）。
作为一个易于获得的参数，入院时的CAR可作为AECOPD患者再入院和频繁加重的独立预测指标。
