Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States.
Org Lett. 2021 Apr 2;23(7):2460-2464. doi: 10.1021/acs.orglett.1c00384. Epub 2021 Mar 19.
The palladium-catalyzed [3 + 2] cycloaddition using generated sulfone-TMM species to construct various chiral cyclopentyl sulfones in a highly regio-, diastereo- (dr >15:1), and enantioselective (up to 99% ee) manner is reported. The present strategy can tolerate different types of sulfone-TMM donors and acceptors, and enables the construction of three chiral centers in a single step, specifically with a chiral center bearing the sulfone moiety. The robust chiral diamidophosphite ligand is the key to the reactivity and selectivities of this transformation.
报道了钯催化的[3+2]环加成反应，利用生成的砜-TMM 物种构建各种手性环戊基砜，具有高度的区域选择性、非对映选择性（dr>15:1）和对映选择性（高达 99%ee）。该策略可以耐受不同类型的砜-TMM 给体和受体，并能在一步中构建三个手性中心，特别是在手性中心上带有砜基。强手性双酰胺基膦配体是该转化反应活性和选择性的关键。
