Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States.
School of Chemistry, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
Org Lett. 2021 Feb 5;23(3):979-983. doi: 10.1021/acs.orglett.0c04169. Epub 2021 Jan 14.
A highly regio-, diastereo-, and enantioselective trimethylenemethane (TMM) cycloaddition reaction for the rapid assembly of 2-acyl-methylenecyclopentane in an atom-economic fashion is described. This intermolecular protocol allows for facile and divergent access to an array of structurally attractive cyclic adducts. The choice of a robust chiral diamidophosphite ligand, developed by our group, proved to be crucial for the success of this transformation.
本文描述了一种高区域、非对映和对映选择性的三甲撑甲烷（TMM）环加成反应，用于快速以原子经济性方式构建 2-酰基亚甲基环戊烷。这种分子间反应协议允许轻松和多样化地获得一系列结构吸引人的环状加合物。我们小组开发的坚固手性双酰胺膦配体的选择被证明是这种转化成功的关键。
