Brooks College of Health, University of North Florida, Jacksonville, Florida, USA.
Health Care Women Int. 2021;42(4-6):726-738. doi: 10.1080/07399332.2021.1882462. Epub 2021 Mar 19.
Medication use during pregnancy carries risks of teratogenicity, preterm birth, and spontaneous abortion. CDC's guidelines advocate for the use of metronidazole for the treatment of bacterial vaginosis (BV) in pregnant women. A literature review assessing the safety of metronidazole during pregnancy was conducted. Metronidazole was found to be effective in preventing preterm births when used in conjunction with other antibiotics. Its use did not predict birth defects or congenital abnormalities. It was however associated with a 70% increased risk of spontaneous abortion. This risk should be interpreted cautiously in light of the confounder which is the severity of genitourinary infection.
孕期用药存在致畸、早产和自然流产的风险。美国疾病预防控制中心的指南提倡使用甲硝唑治疗孕妇细菌性阴道病（BV）。本文对评估孕期甲硝唑安全性的文献进行了综述。甲硝唑与其他抗生素联合使用可有效预防早产。其使用与出生缺陷或先天畸形无关。然而，它与自发性流产风险增加 70%相关。鉴于潜在混杂因素（泌尿生殖系统感染的严重程度），应谨慎解读这一风险。
