Scarselli Alberto, Corfiati Marisa, Di Marzio Davide, Massari Stefania, Marinaccio Alessandro, Iavicoli Sergio
Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority (INAIL), Rome, Italy.
Department of Prevention, Occupational Health and Safety Unit (SPeSAL), Local Health Authority of Bari, Bari, Italy.
Arch Environ Occup Health. 2022;77(5):372-381. doi: 10.1080/19338244.2021.1900045. Epub 2021 Mar 19.
The aim of the study is to investigate exposures to vinyl chloride monomer (VCM) at workplace in Italy and the related burden of diseases. Measurements data was collected from a nation-wide occupational exposure registry (SIREP, 1996-2016). Potentially exposed workers were estimated for some industrial sectors. Concurrent exposures were investigated using cluster analysis. Proportionate mortality ratios were calculated linking data to national mortality statistics (2005-2015). Overall 8,460 measurements were analyzed. Most exposures occurred in the manufacture of chemicals and plastic products. A total of 12,148 workers potentially exposed was estimated (64% male). Concurrent exposures were detected frequently (83%). An elevated proportion of deaths for liver cancer was found in male exposed workers. Although VCM is a known carcinogen for humans, there are still many exposure situations, albeit at low doses, in the chemical and plastic industries.
本研究的目的是调查意大利工作场所中氯乙烯单体（VCM）的暴露情况以及相关的疾病负担。测量数据来自全国职业暴露登记处（SIREP，1996 - 2016年）。对一些工业部门中可能暴露的工人进行了估计。使用聚类分析研究了同时暴露情况。通过将数据与国家死亡率统计数据（2005 - 2015年）相联系，计算了比例死亡率。总共分析了8460次测量。大多数暴露发生在化学品和塑料制品的制造过程中。估计共有12148名工人可能暴露（64%为男性）。经常检测到同时暴露情况（83%）。在暴露的男性工人中发现肝癌死亡比例升高。尽管VCM是一种已知的人类致癌物，但在化学和塑料行业中仍存在许多暴露情况，尽管剂量较低。
