评估意大利工人使用 SIREP 监测系统的抗肿瘤药物和职业暴露情况。
Evaluating Antineoplastic Agents and Occupational Exposures Among Italian Workers Using SIREP Surveillance System.
机构信息
Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority (INAIL), Rome (Mr Scarselli, Mr Di Marzio, Dr Iavicoli); Department of Prevention, Occupational Health and Safety (SPeSAL), Local Health Authority of Bari, Bari (Dr Corfiati), Italy.
出版信息
J Occup Environ Med. 2019 Aug;61(8):669-675. doi: 10.1097/JOM.0000000000001641.
OBJECTIVE
The aim of the study is to evaluate exposures to antineoplastic agents at workplaces in healthcare and manufacturing in Italy.
METHODS
Data on antineoplastic agents were collected from occupational exposure registries. Statistical analysis was carried out for exposure-related variables. The number of workers potentially exposed was estimated for selected industrial sectors. Concurrent exposures were investigated using cluster analysis.
RESULTS
Overall 15,763 exposure situations were analyzed during 1996 to 2016. Most exposures occurred in healthcare (66%). A total of 11,830 workers potentially exposed to antineoplastic agents was estimated. Concurrent exposures were frequently detected in the pharmaceutical industry and among healthcare workers.
CONCLUSIONS
Occupational exposure to antineoplastic agents currently represents a matter of concern both in the chemical industry and in the healthcare sector. The growing number of agents in use supports the need to constantly control exposures.
目的
本研究旨在评估意大利医疗保健和制造业工作场所中抗肿瘤药物的暴露情况。
方法
从职业暴露登记处收集抗肿瘤药物数据。对与暴露相关的变量进行了统计分析。为选定的工业部门估计了潜在暴露于抗肿瘤药物的工人数量。使用聚类分析研究了同时暴露的情况。
结果
在 1996 年至 2016 年期间共分析了 15763 种暴露情况。大多数暴露发生在医疗保健领域（66%）。估计共有 11830 名工人可能接触到抗肿瘤药物。在制药行业和医疗保健工作者中经常同时检测到接触。
结论
目前，职业性接触抗肿瘤药物不仅在化学工业，而且在医疗保健部门都令人关注。越来越多的药物投入使用，这支持了需要持续控制暴露的需要。
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