英格兰关注变种 B.1.1.7 的 SARS-CoV-2 病毒的病死率风险，2020 年 11 月 16 日至 2021 年 2 月 5 日。
Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.
机构信息
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
出版信息
Euro Surveill. 2021 Mar;26(11). doi: 10.2807/1560-7917.ES.2021.26.11.2100256.
The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.
在欧洲，引发关注的 SARS-CoV-2 B.1.1.7 变异株的流行率正在上升。准确评估该变异株相关疾病的严重程度对于大流行规划至关重要。我们发现，与非变异株病例相比，英格兰变异株病例的死亡风险增加（风险比：1.67；95%置信区间：1.34-2.09；p<0.0001）。28 天内死亡的绝对风险随年龄和合并症的增加而增加。与迄今为止的大流行相比，这种变异株具有传播速度更快、死亡率更高的潜在风险。
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