Infectious & Tropical Diseases Unit, "Annunziata", Hospital, Cosenza, Italy.
Hospital Pharmacy, "Annunziata" Hospital, Cosenza, Italy.
Ann Ig. 2021 May-Jun;33(3):205-208. doi: 10.7416/ai.2021.2427.
Oseltamivir caryboxylase is a potent inhibitor of the enzyme neuramidase of the influenza virus particle and it is active against both influenza A and B viruses. Oseltamivir is indicated for therapy or post-exposure prevention of influenza A and B. Side effects are uncommon and include mild nausea, gastrointestinal upset, dizziness and headache. Despite its widespread use, oseltamivir has not been associated with clinically apparent liver injury. To the best of our knowledge, this is the first case report in the literature linking the development of acute hepatitis to the consumption of oseltamivir in a patient suffering from influenza H1N1 infection.
奥司他韦羧酸盐是流感病毒粒子的神经氨酸酶的强效抑制剂，对甲型和乙型流感病毒均具有活性。奥司他韦适用于治疗或暴露后预防甲型和乙型流感。副作用不常见，包括轻度恶心、胃肠道不适、头晕和头痛。尽管广泛使用，但奥司他韦与临床上明显的肝损伤无关。据我们所知，这是首例文献报道，在甲型 H1N1 流感感染患者中，奥司他韦的使用与急性肝炎的发生有关。
