Department of Otorhinolaryngology - Head and Neck Surgery, Inselspital, Bern University Hospital, Freiburgstrasse, 3010, Bern, Switzerland.
Department of Otorhinolaryngology - Head and Neck Surgery, SLK Kliniken Am Gesundbrunnen, 74078, Heilbronn, Germany.
Eur Arch Otorhinolaryngol. 2021 Dec;278(12):4933-4941. doi: 10.1007/s00405-021-06718-4. Epub 2021 Mar 19.
Parapharyngeal space neoplasms (PSNs) are rare tumors of the head and neck region. In this study, we report our institutional experience with PSNs over a 27-years period.
Patients treated between 1992 and 2018 were identified through our tumor board database. Data concerning demographics, clinical presentation, disease features, treatment, complications and follow-up were obtained retrospectively.
In total, 48 patients were identified. Most patients had benign tumors (67.5%), with pleomorphic adenoma and schwannoma being the most frequent entities. Malignant tumors represented the remaining 32.5% of neoplasms. Concerning tissue of origin, 67.5% of neoplasms originated from salivary glands and 17.5% were neurogenic. The vast majority of PSNs required open surgical approaches (77%). The most frequent reversible and irreversible complications included paralysis of facial, vagal, and hypoglossal nerves (transient 62.5%, permanent 31.3%). Tumor recurrences occurred in 16.7% of our patients.
Neoplasms of the parapharyngeal space (PPS) are rare. In our series, consistent with the literature, most patients had benign tumors. Fine-needle aspiration cytology (FNAC) and/or transoral biopsy in selected cases combined with radiographic imaging are helpful to plan the optimal approach (open/transoral) and extent of primary surgery. Close follow-up in malignant neoplasms is crucial to assess recurrence early. We present one of the largest recent studies on PPS tumors treated in a center. Given the low incidence of these tumors, our results contribute to the existing sparse evidence regarding the management and outcome of such tumors.
咽旁间隙肿瘤（PSN）是头颈部罕见的肿瘤。本研究报告了我们机构在 27 年期间治疗 PSN 的经验。
通过我们的肿瘤委员会数据库确定了 1992 年至 2018 年期间治疗的患者。回顾性获得有关人口统计学、临床表现、疾病特征、治疗、并发症和随访的数据。
共确定了 48 例患者。大多数患者患有良性肿瘤（67.5%），其中多形性腺瘤和神经鞘瘤是最常见的实体瘤。恶性肿瘤占肿瘤的其余 32.5%。关于组织起源，67.5%的肿瘤来源于唾液腺，17.5%来源于神经源性。绝大多数 PSN 需要开放手术方法（77%）。最常见的可逆和不可逆转的并发症包括面神经、迷走神经和舌下神经麻痹（暂时性 62.5%，永久性 31.3%）。16.7%的患者出现肿瘤复发。
咽旁间隙肿瘤（PPS）罕见。在我们的系列中，与文献一致，大多数患者患有良性肿瘤。在选择的病例中，细针抽吸细胞学（FNAC）和/或经口活检结合影像学有助于规划最佳的手术方法（开放/经口）和初次手术的范围。在恶性肿瘤中密切随访对于早期评估复发至关重要。我们提出了最近关于在中心治疗的 PPS 肿瘤的最大研究之一。鉴于这些肿瘤的发病率较低，我们的结果为这些肿瘤的管理和结果提供了现有的少量证据。
