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儿童咽旁间隙神经节细胞瘤:1例罕见病例报告

Parapharyngeal Space Ganglioneuroma in a Child: A Report of a Rare Case.

作者信息

Pham Canh T, Nguyen Ha T, Le Tuan A, Dang Thinh D

机构信息

Otolaryngology, Hanoi Medical University, Hanoi, VNM.

Head and Neck Surgery, National Otolaryngology Hospital, Hanoi, VNM.

出版信息

Cureus. 2025 Aug 6;17(8):e89493. doi: 10.7759/cureus.89493. eCollection 2025 Aug.

DOI:10.7759/cureus.89493
PMID:40918922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12412776/
Abstract

Parapharyngeal space (PPS) tumors are extremely rare in the pediatric population, accounting for a small fraction of all head and neck neoplasms. The majority of neoplasms in the PPS are benign tumors. We present a case of an eight-year-old male with a large PPS ganglioneuroma, who presented with a neck mass that had been progressing over five years with no symptoms of dysphasia. Diagnostic imaging, including computed tomography scan and magnetic resonance imaging with contrast, revealed a large, heterogeneously enhancing mass, measuring about 4.47 × 6.49 × 2.56 cm in size, in the right poststyloid PPS. The tumor extended closely from the common carotid artery bifurcation to the skull base, without intracranial extension. A transcervical surgical approach enabled complete tumor excision without complications. Postoperative histopathology confirmed the diagnosis of ganglioneuroma, a very rare case in pediatric PPS tumors. No postoperative complications were noted, and follow-up over two years revealed no signs of recurrence.

摘要

咽旁间隙(PPS)肿瘤在儿科人群中极为罕见,仅占所有头颈部肿瘤的一小部分。PPS中的大多数肿瘤为良性肿瘤。我们报告一例8岁男性患有巨大PPS神经节细胞瘤,该患者颈部肿块已持续进展5年,无吞咽困难症状。诊断性影像学检查,包括计算机断层扫描和增强磁共振成像,显示右侧茎突后PPS有一个巨大的、不均匀强化的肿块,大小约为4.47×6.49×2.56 cm。肿瘤从颈总动脉分叉处紧密延伸至颅底,无颅内延伸。经颈手术入路实现了肿瘤的完整切除且无并发症。术后组织病理学确诊为神经节细胞瘤,这在儿科PPS肿瘤中是非常罕见的病例。未观察到术后并发症,两年的随访未发现复发迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/ffcbc913e569/cureus-0017-00000089493-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/0adb6094588f/cureus-0017-00000089493-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/a46520f26388/cureus-0017-00000089493-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/1c73fbb6b458/cureus-0017-00000089493-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/220d8797c8d5/cureus-0017-00000089493-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/849afe9e58f0/cureus-0017-00000089493-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/76a9649d2907/cureus-0017-00000089493-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/ffcbc913e569/cureus-0017-00000089493-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/0adb6094588f/cureus-0017-00000089493-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/a46520f26388/cureus-0017-00000089493-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/1c73fbb6b458/cureus-0017-00000089493-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/220d8797c8d5/cureus-0017-00000089493-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/849afe9e58f0/cureus-0017-00000089493-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/76a9649d2907/cureus-0017-00000089493-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d40/12412776/ffcbc913e569/cureus-0017-00000089493-i07.jpg

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本文引用的文献

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Primary Pathology of the Parapharyngeal Space.咽旁间隙的原发性病变。
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Parapharyngeal Space Ganglioneuroma: Clinical Experience and Review of the Literature.咽旁间隙神经节细胞瘤:临床经验及文献综述
Ear Nose Throat J. 2023 Dec;102(12):765-771. doi: 10.1177/01455613221142658. Epub 2022 Nov 30.
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