Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Department of Pharmacology, Chongqing Medical University, Chongqing, People's Republic of China.
Adv Exp Med Biol. 2021;1316:117-131. doi: 10.1007/978-981-33-6785-2_8.
Tumor- or cancer-associated fibroblasts (TAFs), one of the most abundant stromal cell types in various carcinomas, consist of a heterogeneous cell population. Typically, TAFs are assigned with pro-tumor activities to promote tumor growth and progression. One of the key features of solid tumors is the metabolic reprogramming that induces alterations of bioenergetics and biosynthesis in both tumor cells and TAFs. Therefore, this review emphasizes TAFs lipid metabolism related to both TAFs differentiation process and TAFs crosstalk with cancer cells. We hope that this review will help understand lipid metabolism in tumor microenvironment, and support the rational design of metabolism-based approaches to improve the efficacy of cancer therapy.
肿瘤相关成纤维细胞（TAFs）是各种癌症中最丰富的基质细胞类型之一，由异质性细胞群组成。通常，TAFs 具有促进肿瘤生长和进展的促肿瘤活性。实体瘤的一个关键特征是代谢重编程，它诱导肿瘤细胞和 TAFs 中的生物能量和生物合成发生改变。因此，本综述强调了与 TAFs 分化过程和 TAFs 与癌细胞相互作用相关的 TAFs 脂质代谢。我们希望本综述将有助于理解肿瘤微环境中的脂质代谢，并支持基于代谢的方法的合理设计，以提高癌症治疗的疗效。
