The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
Mol Cell. 2021 Mar 18;81(6):1128-1129. doi: 10.1016/j.molcel.2021.02.026.
Huang et al. (2021) identified a mechanism acting through the arginine methyltransferase PRMT6 that stabilizes the interaction of RCC1 with chromatin, promoting cell proliferation and tumorigenicity. Targeting this mechanism might enhance the treatment of tumors such as glioblastoma.
Huang 等人（2021 年）发现了一种通过精氨酸甲基转移酶 PRMT6 发挥作用的机制，该机制稳定了 RCC1 与染色质的相互作用，促进了细胞增殖和致瘤性。针对这种机制可能会增强对诸如神经胶质瘤等肿瘤的治疗效果。
