保持专注：PRMT6 驱动 RCC1 定位于染色体，以促进有丝分裂、细胞增殖和肿瘤发生。
Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis.
机构信息
The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
出版信息
Mol Cell. 2021 Mar 18;81(6):1128-1129. doi: 10.1016/j.molcel.2021.02.026.
PMID:33740472
Abstract
Huang et al. (2021) identified a mechanism acting through the arginine methyltransferase PRMT6 that stabilizes the interaction of RCC1 with chromatin, promoting cell proliferation and tumorigenicity. Targeting this mechanism might enhance the treatment of tumors such as glioblastoma.
摘要
Huang 等人（2021 年）发现了一种通过精氨酸甲基转移酶 PRMT6 发挥作用的机制，该机制稳定了 RCC1 与染色质的相互作用，促进了细胞增殖和致瘤性。针对这种机制可能会增强对诸如神经胶质瘤等肿瘤的治疗效果。
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