Faculty of Medicine, the University of Jordan, Amman, 11942, Jordan..
Faculty of Medicine, the University of Jordan, Amman, 11942, Jordan.
Psychiatry Res. 2021 May;299:113856. doi: 10.1016/j.psychres.2021.113856. Epub 2021 Mar 3.
Several observational studies investigated the relationship between pre-diagnosis with mental disorders and COVID-19 outcomes. Thus, we have decided to conduct this meta-analysis to explore this relationship. We complied to the PRISMA guidelines in conducting this meta-analysis. PubMed, ScienceDirect, Google Scholar and medRxiv were searched until the 15th of February, 2021. We used the Random effect model in Meta XL, version 5.3 to pool the included studies. Statistical heterogeneity was assessed using Cochran's Q heterogeneity test and I². This meta-analysis included 634,338 COVID-19 patients from 16 studies. Our findings revealed that pre-diagnosis with mental disorders increased the risk of COVID-19 mortality and severity. This increase in the risk of COVID-19 mortality and severity remained significant in the model that only included the studies that adjusted for confounding variables. Furthermore, higher mortality was noticed in the included studies among schizophrenia, schizotypal and delusional disorders patients compared to mood disorders patients. In this meta-analysis we provided two models which both reported a significant increase in the risk of COVID-19 severity and mortality among patients with mental disorders, and with the upcoming COVID-19 vaccines, we recommend to give this category the priority in the vaccination campaigns along with medical health providers and elderly.
几项观察性研究调查了诊断前精神障碍与 COVID-19 结局之间的关系。因此，我们决定进行这项荟萃分析以探索这种关系。我们按照 PRISMA 指南进行这项荟萃分析。我们检索了 PubMed、ScienceDirect、Google Scholar 和 medRxiv，截至 2021 年 2 月 15 日。我们使用 Meta XL，版本 5.3 中的随机效应模型来合并纳入的研究。使用 Cochran's Q 异质性检验和 I²评估统计异质性。这项荟萃分析包括来自 16 项研究的 634338 名 COVID-19 患者。我们的研究结果表明，诊断前患有精神障碍会增加 COVID-19 死亡和严重程度的风险。在仅包括调整混杂变量的研究的模型中，这种 COVID-19 死亡率和严重程度增加的风险仍然显著。此外，与心境障碍患者相比，包括的研究中精神分裂症、类精神分裂症和妄想障碍患者的死亡率更高。在这项荟萃分析中，我们提供了两种模型，这两种模型都报告称，精神障碍患者 COVID-19 严重程度和死亡率的风险显著增加，随着即将推出的 COVID-19 疫苗，我们建议在疫苗接种活动中优先考虑这一类别，以及医疗保健提供者和老年人。
