All Authors from the Department of Otolaryngology - Head and Neck Surgery, Albany Medical Center, New York, 12208, United States.
All Authors from the Department of Otolaryngology - Head and Neck Surgery, Albany Medical Center, New York, 12208, United States.
Int J Pediatr Otorhinolaryngol. 2021 May;144:110672. doi: 10.1016/j.ijporl.2021.110672. Epub 2021 Mar 11.
To review tumor and patient characteristics as well as survival of pediatric head and neck malignant teratomas (HNMT) in comparison to the adult population.
This investigation was a retrospective cohort study. The Surveillance, Epidemiology, and End Results (SEER) database (SEER-18 Regs Custom registry, November 2018) was reviewed for all cases of head and neck malignant teratomas from 1975 to 2016. A log rank test was used to compare survival between infant, pediatric, and adult HNMT, and between head and neck and non-head and neck malignant teratomas. Infant, pediatric, and adult patients were defined as younger than one year old, younger than 18 years old, and older than 18 years old, respectively.
Sixty-three malignant teratoma cases (1.96%) occurred in the head and neck region from 1975 to 2016, including 11 adult (17.46%) and 52 (82.54%) pediatric patients. 79.37% (50 patients) were diagnosed during infancy. The most common location was the soft tissue of the head and neck in pediatric patients (65.38%) and the thyroid gland in adults (54.54%). The 5-year survival was 45.83% (±7.19%) in infants and 46.00% (±7.05%) in pediatric patients. There were differences in 1-year and 5-year survival between pediatric HNMT and non-head and neck malignant teratomas, (76.01% versus 86.20%) (p = 0.022) and (46.00% versus 67.10%) (p < 0.001), respectively. There was no difference in 1-year and 5-year survival between pediatric patients and adults with HNMT, (76.01% versus 81.81%) (p = 0.618) and (46.00% versus 54.54%) (p = 0.560), respectively.
HNMT occurred most frequently in patients under the age of 1. Prognosis of pediatric HNMT is poor in comparison to pediatric non-head and neck malignant teratomas. Repeat studies after accumulating more patients in the database would be beneficial to confirm our findings.
与成人相比，回顾儿童头颈部恶性畸胎瘤（HNMT）的肿瘤和患者特征以及生存率。
本研究为回顾性队列研究。对 1975 年至 2016 年间来自 SEER-18 登记数据库（SEER-18 定制登记处，2018 年 11 月）的所有头颈部恶性畸胎瘤病例进行了审查。使用对数秩检验比较婴儿、儿科和成人 HNMT 之间以及头颈部和非头颈部恶性畸胎瘤之间的生存率。婴儿、儿科和成人患者的定义分别为年龄小于 1 岁、年龄小于 18 岁和年龄大于 18 岁。
1975 年至 2016 年间，头颈部共发生 63 例恶性畸胎瘤（1.96%），其中成人 11 例（17.46%），儿科 52 例（82.54%）。79.37%（50 例）在婴儿期诊断。最常见的部位是儿科患者的头颈部软组织（65.38%）和成人的甲状腺（54.54%）。婴儿的 5 年生存率为 45.83%（±7.19%），儿科患者为 46.00%（±7.05%）。儿科 HNMT 与非头颈部恶性畸胎瘤在 1 年和 5 年生存率方面存在差异，（76.01%比 86.20%）（p=0.022）和（46.00%比 67.10%）（p<0.001）。儿科患者与 HNMT 成人患者在 1 年和 5 年生存率方面无差异，（76.01%比 81.81%）（p=0.618）和（46.00%比 54.54%）（p=0.560）。
HNMT 最常发生在 1 岁以下的患者中。与儿科非头颈部恶性畸胎瘤相比，儿科 HNMT 的预后较差。在数据库中积累更多患者后进行重复研究将有助于证实我们的发现。
