因果关系在认知控制不同成分中的作用。
Causal role of cross-frequency coupling in distinct components of cognitive control.
机构信息
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
出版信息
Prog Neurobiol. 2021 Jul;202:102033. doi: 10.1016/j.pneurobio.2021.102033. Epub 2021 Mar 16.
Cognitive control is the capacity to guide motor and perceptual systems towards abstract goals. High-frequency neural oscillations related to motor activity in the beta band (13-30 Hz) and to visual processing in the gamma band (>30 Hz) are known to be modulated by cognitive control signals. One proposed mechanism for cognitive control is via cross-frequency coupling whereby low frequency network oscillations in prefrontal cortex (delta from 2-3 Hz and theta from 4-8 Hz) guide the expression of motor-related activity in action planning and guide perception-related activity in memory access. However, there is no causal evidence for cross-frequency coupling in these dissociable components of cognitive control. To address this important gap in knowledge, we delivered cross-frequency transcranial alternating current stimulation (CF-tACS) during performance of a task that manipulated cognitive control demands along two dimensions: the abstraction of the rules of the task (nested levels of action selection) that increased delta-beta coupling and the number of rules (set-size held in memory) that increased theta-gamma coupling. As hypothesized, we found that CF-tACS increased the targeted phase-amplitude coupling and modulated task performance of the associated cognitive control component. These findings provide causal evidence that prefrontal cortex orchestrates different components of cognitive control via two different cross-frequency coupling modalities.
认知控制是引导运动和感知系统朝向抽象目标的能力。与运动活动相关的高频神经振荡（β频段，13-30 Hz）和与视觉处理相关的γ频段（>30 Hz）的神经振荡已知受到认知控制信号的调制。认知控制的一种拟议机制是通过跨频耦合，其中前额叶皮层中的低频网络振荡（δ频段 2-3 Hz 和θ频段 4-8 Hz）引导运动相关活动的表达，用于动作规划，并引导与感知相关的活动，用于记忆访问。然而，在这些可分离的认知控制成分中，没有因果证据表明存在跨频耦合。为了填补这一知识空白，我们在执行一项任务期间提供了跨频经颅交流电刺激（CF-tACS），该任务沿两个维度操纵认知控制需求：任务规则的抽象程度（动作选择的嵌套级别）增加了δ-β耦合，以及规则数量（记忆中保持的集大小）增加了θ-γ耦合。正如假设的那样，我们发现 CF-tACS 增加了目标相位-振幅耦合，并调节了与认知控制相关的认知控制组件的任务表现。这些发现提供了因果证据，表明前额叶皮层通过两种不同的跨频耦合模式来协调认知控制的不同成分。
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