Clancy Julie A, Riddle Justin, Cassano Paolo, Frohlich Flavio
Harvard Medical School, Department of Psychiatry, Boston, Massachusetts (JAC, PC); Division of Neuropsychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts (JAC, PC); Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (JR, FF); Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (JR, FF); Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts (PC); Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts (PC); Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (FF); Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (FF); Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (FF); and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (FF).
Psychiatr Ann. 2022 Nov;52(11):456-460. doi: 10.3928/00485713-20221018-02. Epub 2022 Nov 1.
The 21st century has brought forth major advancements in device-based treatments for psychiatric disorders such as major depressive disorder (MDD). One of the most exciting technologies on the rise in this field is transcranial alternating current stimulation (tACS). The small but rapidly growing body of knowledge on tACS suggests that this wearable, low-cost, noninvasive neuromodulation method could provide a safe and effective alternative, or augmentation, to pharmacological interventions for MDD. While device parameters for treatment of MDD need refinement before this method is ready for standardized clinical use, we expect that tACS will make a significant impact on psychiatric treatment in the coming years.
21世纪在针对诸如重度抑郁症（MDD）等精神疾病的基于设备的治疗方面取得了重大进展。该领域正在兴起的最令人兴奋的技术之一是经颅交流电刺激（tACS）。关于tACS的知识虽少但在迅速增长，这表明这种可穿戴、低成本、非侵入性的神经调节方法可以为MDD的药物干预提供一种安全有效的替代方案或辅助手段。虽然在这种方法准备好用于标准化临床使用之前，治疗MDD的设备参数需要完善，但我们预计tACS在未来几年将对精神科治疗产生重大影响。
