Natural Resources Institute, Federal University of Itajubá, Av. BPS, Pinheirinho, Itajubá, MG, CEP 37500-903, Brazil; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, Bl. 17, São Paulo, SP, CEP 05508-900, Brazil.
Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, Bl. 17, São Paulo, SP, CEP 05508-900, Brazil.
Environ Toxicol Pharmacol. 2021 Jul;85:103634. doi: 10.1016/j.etap.2021.103634. Epub 2021 Mar 16.
Female juveniles of the Neotropical fish Astyanax altiparanae were exposed for 96 h to four treatments containing the active ingredient from Imidacloprid® commercial formulation (IMI 1, IMI 2, IMI 3, and IMI 4) and to a control treatment (only dechlorinated tap water). Glutathione content, glutathione S-transferase activity, lipid peroxidation (LPO) and protein carbonylation levels, acetylcholinesterase (AChE) activity, and frequency of micronuclei and erythrocyte nuclear abnormalities (ENA) were measured in the fish. The muscle and gills were the most affected organs; their antioxidant defense was not enough to prevent oxidative damage (LPO) in the IMI 2 and IMI 4 treatment fish. IMI also inhibited AChE activity in the muscle (IMI 3 and IMI 4) and increased ENA frequency (IMI 4). IMI can affect the health of A. altiparanae in environmentally relevant concentrations, causing oxidative damage in different organs, neurotoxic effects in the muscle, and genotoxicity.
南美胎生鱂（Astyanax altiparanae）的雌性幼鱼在含有吡虫啉（Imidacloprid® 商业配方中的活性成分）的四个处理组中暴露 96 小时，以及一个对照组（仅去氯自来水）。在鱼体内测量了谷胱甘肽含量、谷胱甘肽 S-转移酶活性、脂质过氧化（LPO）和蛋白质羰基化水平、乙酰胆碱酯酶（AChE）活性以及微核和红细胞核异常（ENA）的频率。肌肉和鳃是受影响最严重的器官；它们的抗氧化防御不足以防止 IMI 2 和 IMI 4 处理鱼的氧化损伤（LPO）。IMI 还抑制了肌肉中的 AChE 活性（IMI 3 和 IMI 4）并增加了 ENA 频率（IMI 4）。IMI 可以在环境相关浓度下影响 A. altiparanae 的健康，导致不同器官的氧化损伤、肌肉的神经毒性和遗传毒性。
Zotero 插件