Int J Gynecol Pathol. 2022 Jan 1;41(1):76-81. doi: 10.1097/PGP.0000000000000768.
Ovarian seromucinous borderline tumors (SMBT) and clear cell tumors are both closely associated with endometriosis and share, in a proportion of cases, a molecular pathway involving ARID1A mutations, but they have been rarely described in association. We report a case series of 4 clear cell tumors (3 carcinomas, 1 borderline adenofibroma) coexisting in the same ovary with SMBT. In all cases, the SMBT was the predominant component and we highlight that adequate sampling of these tumors is important to detect small clear cell carcinomas, thus potentially altering the treatment and prognosis.
卵巢浆液性-黏液性交界性肿瘤 (SMBT) 和透明细胞肿瘤均与子宫内膜异位症密切相关，在一部分病例中存在涉及 ARID1A 突变的分子途径，但它们很少同时出现。我们报告了一组 4 例透明细胞肿瘤（3 例癌，1 例交界性腺纤维瘤）在同一卵巢中与 SMBT 共存的病例系列。在所有病例中，SMBT 是主要成分，我们强调对这些肿瘤进行充分的取样对于检测小的透明细胞癌很重要，从而可能改变治疗和预后。
