Vasilakaki T, Skafida E, Arkoumani E, Grammatoglou X, Firfiris N, Manoloudaki K
Department of Pathology, Tzaneion General Hospital of Piraeus, Greece.
Eur J Gynaecol Oncol. 2012;33(2):230-2.
Clear cell tumours of the ovary are relatively uncommon. Most of them are clear cell carcinomas. Benign and borderline clear cell tumours are extremely rare and almost always fibromatous. We report a case of a 34-year-old woman. Ultrasound and computed tomography showed a right ovarian mass 8 cm in diameter. The patient underwent right salpingo-oophorectomy. Microscopic examination revealed glands and cysts different in size and shape within an abundant stromal component without evidence of stromal invasion. Many cysts and glands were lined by a single layer of flattened, cuboidal or hobnail cells with mild to moderate cytologic atypia and prominent nucleoli. Psammomatous calcifications were occasionally indentified. Features of endometriosis were also present adjacent to the tumour. Lesional cells were positive for Ker 7 and CA125. Staining for p53 was focally positive. Based on the above characteristic morphologic and immunohistochemical findings a diagnosis of borderline clear cell adenofibroma was made. The patient was free of recurrence four years after surgery.
卵巢透明细胞瘤相对少见。其中大多数为透明细胞癌。良性和交界性透明细胞瘤极为罕见，且几乎均为纤维瘤样。我们报告一例34岁女性病例。超声和计算机断层扫描显示右侧卵巢有一个直径8厘米的肿块。患者接受了右侧输卵管卵巢切除术。显微镜检查显示，在丰富的间质成分内有大小和形状各异的腺体和囊肿，无间质浸润证据。许多囊肿和腺体衬以单层扁平、立方形或鞋钉样细胞，具有轻度至中度细胞学异型性和明显核仁。偶尔可见砂粒体钙化。肿瘤旁还存在子宫内膜异位症特征。病变细胞Ker 7和CA125呈阳性。p53染色局灶阳性。基于上述特征性形态学和免疫组化结果，诊断为交界性透明细胞腺纤维瘤。患者术后四年无复发。
