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Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?

作者信息

Christ Torsten, Lemoine Marc D, Eschenhagen Thomas

机构信息

Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.

出版信息

Nat Commun. 2021 Mar 19;12(1):1725. doi: 10.1038/s41467-021-21949-z.

DOI:10.1038/s41467-021-21949-z
PMID:33741918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7979815/
Abstract
摘要

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Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?源自人多能干细胞的心房心肌细胞是否已准备好用于鉴定治疗心房颤动的药物？
Nat Commun. 2021 Mar 19;12(1):1725. doi: 10.1038/s41467-021-21949-z.
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Reply to 'Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?'.对“源自人类多能干细胞的心房心肌细胞是否已准备好用于鉴定治疗心房颤动的药物？”的回复
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Reply to 'Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?'.对“源自人类多能干细胞的心房心肌细胞是否已准备好用于鉴定治疗心房颤动的药物？”的回复
Nat Commun. 2021 Mar 19;12(1):1729. doi: 10.1038/s41467-021-21950-6.

本文引用的文献

1
Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (I).病例报告：人诱导多能干细胞心肌细胞中的早期后除极——大电导钙激活钾电流（I）的一种假象。
Cells. 2020 Jan 20;9(1):253. doi: 10.3390/cells9010253.
2
Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes.从心室和心房人多能干细胞来源的心肌细胞生成环形工程心脏组织。
Nat Commun. 2020 Jan 7;11(1):75. doi: 10.1038/s41467-019-13868-x.
3
Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium.心房样工程心脏组织：人类心房的体外模型。
Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.
4
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Circ Arrhythm Electrophysiol. 2018 Jul;11(7):e006035. doi: 10.1161/CIRCEP.117.006035.
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Cell Stem Cell. 2017 Aug 3;21(2):179-194.e4. doi: 10.1016/j.stem.2017.07.003.
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EMBO Mol Med. 2015 Apr;7(4):394-410. doi: 10.15252/emmm.201404757.
7
The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation.新型抗心律失常药物 vernakalant：窦性节律和慢性心房颤动患者心房组织的离体研究。
Cardiovasc Res. 2013 Apr 1;98(1):145-54. doi: 10.1093/cvr/cvt006. Epub 2013 Jan 22.
8
The comparative sensitivity of three in vitro safety pharmacology models for the detection of lidocaine-induced cardiac effects.三种体外安全药理学模型检测利多卡因诱导的心脏效应的比较敏感性
J Pharmacol Toxicol Methods. 2012 Jul;66(1):52-8. doi: 10.1016/j.vascn.2012.06.001. Epub 2012 Jun 9.
9
Vernakalant hydrochloride for rapid conversion of atrial fibrillation: a phase 3, randomized, placebo-controlled trial.盐酸维那卡兰用于心房颤动的快速转复：一项3期随机安慰剂对照试验。
Circulation. 2008 Mar 25;117(12):1518-25. doi: 10.1161/CIRCULATIONAHA.107.723866. Epub 2008 Mar 10.
10
Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine.心房选择性钠通道阻滞作为抑制心房颤动的策略：心房与心室钠通道失活的差异及雷诺嗪的作用
Circulation. 2007 Sep 25;116(13):1449-57. doi: 10.1161/CIRCULATIONAHA.107.704890. Epub 2007 Sep 4.