Dutch Perioperative Allergy Centre, Amsterdam University Medical Centres, Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands; Department of Anaesthesiology, Amsterdam University Medical Centres, Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Department of Anaesthesiology, Amsterdam University Medical Centres, Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Best Pract Res Clin Anaesthesiol. 2021 May;35(1):11-25. doi: 10.1016/j.bpa.2020.03.003. Epub 2020 Apr 3.
Perioperative allergic reactions are rare, yet important complications of anesthesia. Severe, generalized allergic reactions called anaphylaxis are estimated to have a mortality of 3.5-4.8%. Adequate recognition and handling of a severe perioperative anaphylactic reaction result in better outcomes, including less hypoxic-ischemic encephalopathy and death. The diagnosis of a perioperative allergic reaction can be difficult as the list of possible culprits of a perioperative allergic reaction is extensive. Making an informed guess on the causative agent and avoiding this agent in future anesthesia procedures is undesirable and unsafe. Therefore, to ensure future patient safety, a thorough investigation following a perioperative allergic reaction is mandatory. A collaborate approach by allergists and anesthesiologists is advised. In this article, we discuss the basic approach of the allergic patient and of patients with a suspected allergy to perioperatively administered medication.
围手术期过敏反应罕见，但却是麻醉的重要并发症。严重的全身性过敏反应，称为过敏反应，估计死亡率为 3.5-4.8%。充分认识和处理严重围手术期过敏反应可改善结局，包括缺氧缺血性脑病和死亡减少。围手术期过敏反应的诊断可能很困难，因为围手术期过敏反应的可能原因很多。猜测导致过敏反应的原因并在未来的麻醉程序中避免使用该药物是不可取且不安全的。因此，为了确保未来患者的安全，必须对围手术期过敏反应进行彻底调查。建议过敏症专家和麻醉师采取协作方法。在本文中，我们讨论了过敏患者和疑似围手术期用药过敏患者的基本处理方法。
